Effect of dienogest-containing oral contraceptives on lipid metabolism

Contraception
I WiegratzH Kuhl

Abstract

In a double-blind, controlled, randomized, four-arm, bicentric clinical study, the effect of four oral contraceptives (OCs) on lipid metabolism was investigated. Four groups composed of 25 volunteers each (mean age 26.1 +/- 4.5 years; body mass index 21.9 +/- 2.8 kg/m(2)) were treated for six cycles with monophasic combinations containing 21 tablets with either 30 microg ethinyl estradiol (EE) + 2 mg dienogest (DNG) (30 EE/DNG), 20 microg EE + 2 mg DNG (20 EE/DNG), 10 microg EE + 2 mg estradiol valerate (EV) + 2 mg DNG (EE/EV/DNG), or 20 microg EE + 100 microg levonorgestrel (LNG; EE/LNG). The study was completed by 91 women. Blood samples were taken by venipuncture after at least 12 h fasting on Days 21-26 of the control cycle and Days 18-21 of the first, third, and sixth treatment cycle. There were clear differences between the effects of EE/LNG and the formulations containing estrogens and DNG. Although EE/LNG did not change the triglycerides levels, a significant increase was observed during treatment with the DNG-containing preparations. Although EE/LNG significantly reduced HDL-CH and HDL(2)-CH, there was a nonsignificant increase with the DNG-containing OCs. No change was observed in the levels of HDL(3)-CH. A significan...Continue Reading

References

Oct 11, 1992·American Journal of Obstetrics and Gynecology·R M Krauss, R T Burkman
Jul 1, 1990·American Journal of Obstetrics and Gynecology·H KuhlW Gross
Oct 1, 1985·American Journal of Obstetrics and Gynecology·W MärzH Kuhl
Jan 1, 1987·Acta Obstetricia Et Gynecologica Scandinavica·S BertoliniL De Cecco
Jun 1, 1987·British Journal of Obstetrics and Gynaecology·N van der VangeA A Haspels
Aug 1, 1983·The Journal of Clinical Endocrinology and Metabolism·E J SchaeferR I Levy
Apr 1, 1983·Metabolism: Clinical and Experimental·S M HaffnerW R Hazzard
Mar 15, 1982·American Journal of Obstetrics and Gynecology·C R Kay
Mar 15, 1982·American Journal of Obstetrics and Gynecology·V Wynn, R Niththyananthan
Jun 1, 1982·The Journal of Clinical Endocrinology and Metabolism·M J TikkanenS U Sipinen
May 29, 1981·Biochemical and Biophysical Research Communications·K ShiraiR L Jackson
May 1, 1993·The Journal of Clinical Investigation·B W Walsh, F M Sacks
Jan 25, 2002·Current Controlled Trials in Cardiovascular Medicine·Curt D Furberg

❮ Previous
Next ❯

Citations

May 4, 2011·Reviews in Endocrine & Metabolic Disorders·Regine Sitruk-Ware, Anita Nath
Feb 7, 2013·Best Practice & Research. Clinical Endocrinology & Metabolism·Regine Sitruk-Ware, Anita Nath
Apr 6, 2004·Maturitas·Regine Sitruk-Ware
Apr 17, 2010·Drugs·Ezequiel F Pérez-Campos
Aug 1, 2015·Journal of Endocrinological Investigation·M FarahmandF Azizi
Oct 12, 2010·Contraception·Regine Sitruk-Ware, Anita Nath
Oct 13, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Günter KöhlerAlfred O Mueck
Dec 3, 2003·Annals of the New York Academy of Sciences·Vincenza BruniPaolo Vangelisti
Dec 1, 2011·Journal of Clinical Pharmacology·Christine KlippingBarbara Schuett
May 27, 2015·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Iñaki LeteAxelle Pintiaux
Oct 24, 2006·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·Inka Wiegratz, Herbert Kuhl
Jun 12, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Giovanni GrandiAngelo Cagnacci
May 18, 2016·Expert Opinion on Drug Metabolism & Toxicology·Giovanni GrandiAngelo Cagnacci
Dec 5, 2002·Pharmacoepidemiology and Drug Safety
Jun 6, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Barry E HurwitzRonald B Goldberg
Jan 31, 2014·The Cochrane Database of Systematic Reviews·Maria F GalloFrans M Helmerhorst
Nov 18, 2005·Human Reproduction Update·Regine Sitruk-Ware
Oct 17, 2017·Frontiers in Endocrinology·Júnia Raquel Dutra FerreiraMarilda de Souza Gonçalves

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.