Abstract
Epidemiological studies have shown that particulate matter (PM) is associated with adverse respiratory health effects. Although infection in the respiratory organ is one of the most important health risks the association of infection with PM is not fully understood. As we had hypothesized that diesel exhaust particles (DEP), one of the major component of PM, may induce the expression of receptors for viruses and bacteria at invasion sites, we studied the effect of DEP on the mRNA expression of intercellular adhesion molecule-1 (ICAM-1), low-density lipoprotein (LDL) and platelet-activating factor (PAF) receptors, which are invasion sites of virus and bacteria, on rat lung epithelial cells. The real-time quantitative polymerase chain reaction (PCR) method was used for the evaluation. All of these mRNAs were up-regulated by 3, 10, and 30 microg/ml of DEP in a concentration-dependent manner. The up-regulation of each was associated with the mRNA expression of heme oxygenase-1 (HO-1), a marker of oxidative stress. Our present results show that DEP up-regulated the mRNA expression of viral and bacterial receptors. This up-regulation might be associated with DEP-induced oxidative stress. These results thus suggest that DEP may enhanc...Continue Reading
References
Apr 1, 1992·Respiration Physiology·H J Colebatch, C K Ng
Mar 10, 1989·Cell·J M GreveA McClelland
Oct 5, 1995·Nature·D R CundellE I Tuomanen
Aug 11, 1995·The Journal of Biological Chemistry·K A RoebuckA B Malik
Dec 9, 1993·The New England Journal of Medicine·D W DockeryF E Speizer
May 10, 1993·FEBS Letters·H MutohT Shimizu
Jun 1, 1996·Journal of Applied Physiology·R H StephensD V Walters
Jan 1, 1997·Clinical Microbiology Reviews·R A Miller, B E Britigan
Aug 12, 1999·Archives of Environmental Health·G RossiJ Schwartz
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·N LiA Nel
Sep 9, 2000·Experimental Gerontology·Y LavrovskyA K Roy
Feb 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·T SuzukiH Sasaki
Apr 18, 2001·American Journal of Respiratory Cell and Molecular Biology·S IshizukaH Sasaki
Mar 26, 2003·American Journal of Respiratory Cell and Molecular Biology·Kevin S HarrodMatthew D Reed
Oct 16, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Kevin S HarrodMatthew D Reed
Nov 16, 2004·Toxicology and Applied Pharmacology·Eiko KoikeTakahiro Kobayashi
Citations
Dec 12, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Hui-Juan CaoHiroshi Kurihara
Feb 14, 2008·The Journal of Infectious Diseases·Yi-Hsuan WuDaniel Tsun-Yee Chiu
May 29, 2013·Cell Biochemistry and Biophysics·Yangzhe WuJohn R Stevens
May 6, 2015·International Journal of Molecular Medicine·Bo LiHan Jung Chae
Apr 7, 2010·Toxicology Letters·Tuya SharkhuuM Ian Gilmour
Nov 11, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Naomi TsukueToru Nakajima
Jun 10, 2008·Toxicology Letters·Shannan RodriguezElizabeth Hong-Geller
Feb 5, 2008·Neuroscience Letters·Markus G KlassMarie Csete
Sep 4, 2007·Mutation Research·Pernille Høgh DanielsenPeter Møller
May 26, 2009·Toxicology·Salik HussainFrancelyne Marano
Feb 28, 2007·Allergy·N G PapadopoulosS L Johnston
Sep 8, 2010·The Journal of Allergy and Clinical Immunology·Shuk-Mei Ho
Sep 21, 2013·Journal of Ethnopharmacology·Qiang LiuZhanqiu Yang
Dec 21, 2006·Journal of Applied Toxicology : JAT·Ken-ichiro InoueToshikazu Yoshikawa
Jan 13, 2010·Inhalation Toxicology·Naomi TsukueToru Nakajima
Oct 31, 2018·Respiratory Research·Dennis LoCynthia J Koziol-White
Nov 8, 2007·Inhalation Toxicology·Jonathan Ciencewicki, Ilona Jaspers
Oct 7, 2020·Annals of the New York Academy of Sciences·Brittany WoodbyGiuseppe Valacchi
Aug 19, 2020·Environmental Pollution·Michael Hendryx, Juhua Luo
Sep 21, 2021·Physiological Reports·Loretta MüllerPhilipp Latzin