Effect of diet in females (F1) from prenatally undernourished mothers on metabolism and liver function in the F2 progeny is sex-specific

European Journal of Nutrition
Ouma CisséChristine Laborie

Abstract

Poor maternal nutrition sensitises to the development of metabolic diseases and obesity in adulthood over several generations. The prevalence increases when offspring is fed with a high-fat (HF) diet after weaning. This study aims to determine whether such metabolic profiles can be transmitted to the second generation and even aggravated when the mothers were exposed to overnutrition, with attention to potential sex differences. Pregnant Wistar rats were subjected to ad libitum (control) or 70% food-restricted diet (FR) during gestation (F0). At weaning, F1 females were allocated to three food protocols: (1) standard diet prior to and throughout gestation and lactation, (2) HF diet prior to and standard diet throughout gestation and lactation, and (3) HF diet prior to and throughout gestation and lactation. F2 offspring was studied between 16 and 32 weeks of age. FR-F2 offspring on standard diet showed normal adiposity and had no significant metabolic alterations in adulthood. Maternal HF diet resulted in sex-specific effects with metabolic disturbances more apparent in control offspring exposed to HF diet during gestation and lactation. Control offspring displayed glucose intolerance associated with insulin resistance in femal...Continue Reading

References

Jul 14, 2000·American Journal of Physiology. Endocrinology and Metabolism·M H VickersP D Gluckman
Jan 26, 2002·British Medical Bulletin·C N Hales, D J Barker
Dec 14, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael G Ross, Mina Desai
Jan 18, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Peter D GluckmanAlan S Beedle
Apr 21, 2007·Journal of Internal Medicine·D J P Barker
Jul 24, 2007·Psychoneuroendocrinology·Didier VieauJean Lesage
Aug 25, 2007·Journal of Lipid Research·Danielle M Schwartz, Nathan E Wolins
Jul 4, 2008·The New England Journal of Medicine·Peter D GluckmanKent L Thornburg
Nov 20, 2008·Diabetes·Josep C Jimenez-ChillaronMary-Elizabeth Patti
Dec 18, 2008·American Journal of Physiology. Endocrinology and Metabolism·Christophe BretonDidier Vieau
Apr 15, 2010·The Biochemical Journal·Matthew J Warner, Susan E Ozanne
May 21, 2010·Hormones and Behavior·Gregory A DunnTracy L Bale
Nov 18, 2010·American Journal of Human Biology : the Official Journal of the Human Biology Council·Jonathan C K Wells
Jun 30, 2011·American Journal of Physiology. Endocrinology and Metabolism·Marie-Amélie LukaszewskiChristophe Breton
Jul 9, 2011·The British Journal of Nutrition·Nayara Peixoto-SilvaAlessandra Pinheiro-Mulder
Oct 25, 2011·Molecular and Cellular Endocrinology·Carlos Guerrero-Bosagna, Michael K Skinner
May 31, 2012·Diabetologia·A A VaagC Brøns
Oct 20, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Catherine E Aiken, Susan E Ozanne
Jan 26, 2013·BJOG : an International Journal of Obstetrics and Gynaecology·M V E VeenendaalT J Roseboom
Feb 26, 2013·Cellular and Molecular Life Sciences : CMLS·Mary-Elizabeth Patti
Aug 9, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M S BakerR A Waterland
Oct 2, 2013·Human Reproduction Update·Catherine E Aiken, Susan E Ozanne
Mar 19, 2014·American Journal of Obstetrics and Gynecology·Mina DesaiMichael G Ross
May 6, 2014·American Journal of Obstetrics and Gynecology·Melissa A SuterKjersti M Aagaard
Jul 26, 2014·Annals of Nutrition & Metabolism·M H Vickers
Nov 15, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Danielle GoodspeedKjersti M Aagaard
Jan 9, 2015·The Journal of Experimental Biology·Anne TarradeAnne Gabory
Aug 5, 2015·Endocrinology·Cheryl S Rosenfeld
Nov 18, 2015·The Proceedings of the Nutrition Society·Josep C Jimenez-ChillaronRuben Diaz
Nov 27, 2015·The British Journal of Nutrition·C J BautistaE Zambrano
Dec 29, 2015·Molecular and Cellular Biochemistry·Mervat Y HanafiMaher A Kamel
Jan 13, 2016·Comprehensive Physiology·Jan P Buschdorf, Michael J Meaney

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