Effect of diet on serum accumulation and renal excretion of aryl acids and secretory activity in normal and uremic man.

The American Journal of Clinical Nutrition
W F Cathcart-RakeJ J Grantham

Abstract

The influence of diet on aryl acid metabolism was determined in normal and azotemic subjects. Aryl acid content of serum and urine was estimated by fluorometry in relation to hippuric acid as a standard (FI-Hipp). Secretory activity, a reflection of the biological potency of aromatic acids in serum and urine, was determined by bioassay. The urinary excretion of FI-Hipp and secretory activity of five normal persons on an ad lib diet was 0.78 and 2.25 mM/day, respectively; similar values were observed in two subjects with chronic renal insufficiency. Subjects were fed prunes and cranberries, since these foods contain abundant quantities of hippurate precursors. Prunes 1.5 g/kg body weight, caused the urinary excretion of both FI-Hipp and secretory activity to increase about tenfold in normal and azotemic subjects. Prune feeding caused the serum levels of FI-Hipp and secretory activity to increase about threefold. Cranberries increased the renal excretion of FI-Hipp and secretory activity as did the ingestion of a beverage containing benzoate as a preservative. On the basis of these studies it is clear that diet is an important determinant of the load of aryl acids for urinary excretion; in patients with renal insufficiency the i...Continue Reading

Citations

Sep 21, 2010·BMC Gastroenterology·Horace R T WilliamsTimothy R Orchard
Jun 26, 2015·Metabolomics : Official Journal of the Metabolomic Society·Abdul-Hamid EmwasDavid S Wishart
Jul 23, 2016·Journal of the American Society of Nephrology : JASN·Manjula Kurella TamuraUNKNOWN FHN Study
Jan 1, 1979·Scandinavian Journal of Gastroenterology·C J MitchellJ Kelleher
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