Effect of dietary beta-carotene on the survival of young and old mice

Gerontology
H R MassieL K DeWolfe

Abstract

Feeding 0.5% beta-carotene in the diet for life beginning at 29 days of age improved the average life span of C57BL/6J male mice by 5.0% but decreased the life span of mice started at 608 days of age by 11.5%. Neither difference, however, proved to be statistically significant. Feeding beta-carotene increased the concentration of beta-carotene in the serum by 60% but did not change the beta-carotene content of heart, liver or kidney. We conclude that singlet oxygen, which is very efficiently quenched by beta-carotene, is an important factor in senescence only if it is produced at organ sites not accessible to serum beta-carotene. Since we have found that beta-carotene feeding is not a useful means for increasing tissue concentrations of beta-carotene, other more sophisticated means must be developed for accomplishing this purpose. It is also clear that while dietary beta-carotene is not an effective means for prolonging life span, it is nontoxic when fed continuously at high concentrations.

Citations

Nov 1, 1993·Experimental Gerontology·H R MassieJ L Hough
Nov 26, 2010·Critical Reviews in Food Science and Nutrition·Kua Chong-Han
Aug 21, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ekaterina LashmanovaAlexey Moskalev
Jun 21, 2020·Antioxidants·Ekaterina ProshkinaAlexey Moskalev

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