PMID: 6411526Sep 1, 1983Paper

Effect of dietary cereals on intestinal permeability in experimental enteropathy in rats

Gut
J S Sandhu, D R Fraser

Abstract

A sensitivity to dietary cereal has been reported previously in niacin-deficient rats by measuring a change in the intestinal absorption of radioactively-labelled cellobiotol and mannitol. The possibility that other stimuli could produce this sensitivity, the range of cereals that could induce the permeability change and the nature of the toxic component in cereal have now all been investigated. Treatment with triparanol induces sensitivity in rats to wheat, rye, barley, oats, and maize but not to rice or soybean. These cereals caused a similar response in niacin-deficient rats. Mucosal damage produced by methotrexate or cetrimide, however, did not sensitise the intestinal mucosa to dietary cereals. Gluten, zein, and pepsin/trypsin digests of gluten all induced the permeability defect in triparanol-treated rats. It is concluded that although gross disruption of the mucosal structure may not sensitise rats to cereals, various causes of mucosal cell damage can produce a susceptibility to gluten toxicity that resembles gluten-sensitivity in man.

References

Jan 1, 1978·Journal of Nutritional Science and Vitaminology·Y NakashimaS Kawada
Dec 1, 1965·The American Journal of Digestive Diseases·J R McPherson, R G Shorter
Jan 1, 1981·Clinical Science·I CobdenA T Axon
Dec 15, 1981·The Biochemical Journal·J S Sandhu, D R Fraser

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Citations

Jan 1, 1986·Transactions of the Royal Society of Tropical Medicine and Hygiene·S O UkabamB T Cooper
Aug 1, 1984·Biological Reviews of the Cambridge Philosophical Society·M L Gardner
May 1, 1988·Gut·I Cobden
Nov 1, 1995·The International Journal of Neuroscience·M A CastanyJ Bures
Feb 1, 1991·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·G JenningsM Elia
Dec 29, 2013·Journal of Virology·Claudia IstrateLennart Svensson
May 1, 1986·Diabetic Medicine : a Journal of the British Diabetic Association·S VaalerO Aagenaes

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