Effect of dietary chitosans with different viscosity on plasma lipids and lipid peroxidation in rats fed on a diet enriched with cholesterol

Bioscience, Biotechnology, and Biochemistry
M T ChiangH C Chen

Abstract

To investigate the effect of dietary chitosan on lipid metabolism, male SD (Sprague-Dawley) rats were fed a cholesterol-enriched diet containing 5% cellulose (CE), 5% chitosan (CCS; high viscosity), or 5% chitosan (FCS; low viscosity) for 4 weeks. The two types of chitosan with a comparable degree of deacetylation had a different molecular weight and intrinsic viscosity. Significantly (p < 0.05) lower plasma total cholesterol, LDL-cholesterol and VLDL-cholesterol concentrations were observed in the rats fed on the chitosan diets. In addition, chitosan significantly increased the fecal cholesterol and triglyceride contents. Although no significant difference in body weight was found among the dietary groups, the rats fed on the chitosan diets had lower relative liver weight when compared with those fed on the cellulose diet. Both of the chitosan groups had significantly lower liver total lipid and total cholesterol contents compared to the cellulose group, although the FCS group was less effective. The plasma and liver thiobarbituric acid reactive substances (TBAR) values were similar in the CE and FCS groups, while the CCS group had increased liver TBAR values. Although a significant increase in liver glucose-6-phosphate dehydr...Continue Reading

References

May 1, 1978·Analytical Biochemistry·M Mihara, M Uchiyama
Sep 15, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·S E Carlson, S Goldfarb
Oct 1, 1991·International Journal of Biological Macromolecules·W WangW Qin
Aug 1, 1988·Journal of Applied Physiology·L S CrouchJ B Warshaw
Oct 1, 1988·Proceedings of the Society for Experimental Biology and Medicine·C D JenningsJ W Anderson
Dec 1, 1983·The Journal of Nutrition·D M Hungerford, M C Linder
Apr 1, 1980·The American Journal of Clinical Nutrition·M SuganoY Hasegawa
Mar 1, 1993·Endocrinology·J G LeHoux, F Grondin
May 1, 1995·Bioscience, Biotechnology, and Biochemistry·O KanauchiE Kobayashi
Apr 1, 1994·Journal of Nutritional Science and Vitaminology·Y F Lu, H L Wu
Sep 8, 1998·International Journal of Biological Macromolecules·R H Chen, M L Tsaih

❮ Previous
Next ❯

Citations

Oct 12, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Michela MoriHélder A Santos
May 8, 2008·Journal of the American College of Nutrition·Niina S TapolaAlexander G Schauss
Mar 8, 2008·Bioscience, Biotechnology, and Biochemistry·Haruhide UdagawaToshichika Takita
Jul 26, 2011·International Journal of Food Sciences and Nutrition·Cheong-Rak ChoiPyo-Jam Park
May 20, 2014·The Kaohsiung Journal of Medical Sciences·Eda OzcelikHadi Karimi
Nov 11, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Makoto AnrakuHisao Tomida
Feb 8, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hsien-Tsung YaoMeng-Tsan Chiang
Sep 18, 2016·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Thanchanit Thaipitakwong, Pornanong Aramwit
Oct 30, 2016·Toxicology Mechanisms and Methods·João Soeiro TeodoroCarlos Marques Palmeira
May 27, 2010·Pharmaceutics·Taira YasufukuHisao Tomida
Sep 6, 2018·Journal of Medicinal Food·Ah Ra DoMyung-Sook Choi
Apr 7, 2007·Bulletin of Experimental Biology and Medicine·A S KoryaginA V Mal'kov
Dec 6, 2010·Materials·Roberto Ruiz-Caro, María D Veiga
Apr 25, 2019·Polymers·Masayuki IshiharaHidemi Hattori
Apr 20, 2010·Journal of Agricultural and Food Chemistry·Shing-Hwa LiuMeng-Tsan Chiang
May 8, 2007·European Journal of Pharmacology·Giampietro BondiolottiUmberto Cornelli
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shing-Hwa LiuMeng-Tsan Chiang
Feb 16, 2007·Journal of Agricultural and Food Chemistry·Il Jin ChoTae Youl Ha
Mar 16, 2006·Journal of Agricultural and Food Chemistry·Shu Hui HuJinn Chyi Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.