Effect of dietary cholesterol on phosphatidylcholines and phosphatidylethanolamines in bile and gallbladder mucosa in the prairie dog

Gastroenterology
M L BookerW W La Morte

Abstract

Humans with cholesterol gallstones have been reported to have alterations in the molecular species of phospholipids in bile. Both decreases in phospholipids with linoleic acid and increases in those with arachidonic acid have been found. The purpose of this study was to investigate the effect of a lithogenic diet (0.34% cholesterol) on the relative abundance of individual molecular species of phospholipids in the biliary tract of the prairie dog. In hepatic bile, cholesterol feeding resulted in increases in phospholipid species containing arachidonate and decreases in the major species containing its precursor, linoleate. In gallbladder bile of both control and cholesterol-fed animals, phospholipid species containing linoleate were significantly less abundant than in hepatic bile, suggesting that linoleoyl species were selectively absorbed by the gallbladder epithelium. This apparent uptake was significantly increased by cholesterol feeding. Phosphatidylcholines and phosphatidylethanolamines containing arachidonate were also significantly increased in the gallbladder mucosa of the cholesterol-fed animals. These increases in arachidonate-containing phospholipids in the gallbladder mucosa may contribute to the increase in gallbla...Continue Reading

Citations

Jan 1, 1992·Digestive Diseases and Sciences·K D SaundersJ J Roslyn
Feb 1, 1993·Scandinavian Journal of Gastroenterology·S HatsushikaG Kajiyama
Jan 1, 1993·Digestive Diseases and Sciences·K Saunders-KirkwoodJ J Roslyn
Jul 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F BerrU Frick
Sep 11, 1998·The American Journal of Gastroenterology·P PazziS Gullini
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W W LaMorteS Kay
Mar 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y Peled, T Gilat
Jan 1, 1996·Journal of Clinical Gastroenterology·R K TandonB M Kapur
Oct 1, 1991·European Journal of Clinical Investigation·N Busch, S Matern
Jan 1, 1995·Scandinavian Journal of Gastroenterology. Supplement·P PortincasaG P van Berge-Henegouwen
Aug 1, 2009·Journal of Pediatric Gastroenterology and Nutrition·Wolfram HallerPatrick J McKiernan
Apr 23, 1992·Biochimica Et Biophysica Acta·R Coleman, K Rahman
Mar 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S I Myers

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