Effect of dietary cholesterol with or without saturated fat on plasma lipoprotein cholesterol levels in the laboratory opossum (Monodelphis domestica) model for diet-induced hyperlipidaemia

The British Journal of Nutrition
R S KushwahaJohn L VandeBerg

Abstract

Laboratory opossums (Monodelphis domestica) show extreme genetic variability in their responsiveness to dietary lipids; a great proportion of the genetic variability in responsiveness is due to a single major gene. To determine whether the major gene for dietary response detected by genetic analysis in opossums is responsive to dietary cholesterol or dietary saturated fat, or a combination of both, we used males and females of susceptible and resistant lines of laboratory opossums that were 5 to 7 months old. The animals were challenged with three different experimental diets (high-cholesterol diets with or without high saturated fat from lard or coconut oil) and plasma lipoproteins were measured. Plasma and VLDL+LDL-cholesterol concentrations increased several-fold when the animals were fed the diet containing elevated cholesterol (P<0.001) or elevated cholesterol and fat (P<0.001) and differed between the two lines when they were fed high-cholesterol diets with or without fat (P<0.001). Plasma HDL-cholesterol concentrations were higher (P<0.05) in animals of the resistant line than in the susceptible line when they were fed the basal diet (550 (SEM 30) v. 440 (SEM 20) mg/l) and when they were fed the low-cholesterol and high-...Continue Reading

References

Sep 1, 1992·The American Journal of Clinical Nutrition·G E MottC A McMahan
May 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·P M CliftonP J Nestel
Sep 1, 1989·The American Journal of Clinical Nutrition·M KestinP J Nestel
Jan 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·H C McGillT J Kuehl
Jan 1, 1997·World Review of Nutrition and Dietetics·R S Kushwaha, H C McGill

❮ Previous
Next ❯

Citations

May 5, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jeannie ChanJohn L VandeBerg
Aug 20, 2010·Journal of Nutrition and Metabolism·Jeannie ChanJohn L Vandeberg
May 22, 2010·Journal of Lipid Research·Jeannie ChanJohn L VandeBerg
Jul 24, 2010·Journal of Lipid Research·Candace M KammererPaul B Samollow
Dec 19, 2015·Critical Reviews in Clinical Laboratory Sciences·Menuka Pallebage-GamarallageJohn Mamo
Jan 21, 2015·Lab Animal·Monica Harrington
Nov 29, 2007·American Journal of Physiology. Endocrinology and Metabolism·Mario SiervoSusan A Jebb

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.