Effect of Dietary Complex Lipids on the Biosynthesis of Piglet Brain Gangliosides

Journal of Agricultural and Food Chemistry
Marlon M ReisNicole Roy

Abstract

Gangliosides, found in mammalian milk, are known for their roles in brain development of the newborn. However, the mechanism involved in the impact of dietary gangliosides on brain metabolism is not fully understood. The impact of diets containing complex lipids rich in milk-derived ganglioside GD3 on the biosynthesis of gangliosides (assessed from the incorporation of deuterium) in the frontal lobe of a piglet model is reported. Higher levels of incorporation of deuterium was observed in the GM1 and GD1a containing stearic acid in samples from piglets fed milk containing 18.2 μg/mL of GD3 compared to that in those fed milk containing 25 μg/mL of GD3. This could suggest that the gangliosides from the diet may be used as a precursor for de novo biosynthesis of brain gangliosides or lead to the reduction of de novo biosynthesis of these gangliosides. This effect was more pronounced in the left compared to that in the right brain hemisphere.

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Citations

Oct 26, 2016·Chemistry and Physics of Lipids·Mariza Gomes ReisMarlon Martins Dos Reis
Feb 17, 2021·Bioscience, Biotechnology, and Biochemistry·Xiaoxu WangJie Xu
Feb 24, 2019·Progress in Lipid Research·Wei WeiXingguo Wang
Mar 17, 2021·The Journal of Dairy Research·Roberta Claro da SilvaSalam A Ibrahim

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