Effect of dietary high molybdenum on peripheral blood T-cell subsets and serum IL-2 contents in broilers

Biological Trace Element Research
Jie XiaoYun Cui

Abstract

The objectives of this study were to investigate the effects of dietary high molybdenum (Mo) on immune function by determining changes of the subsets of peripheral blood T-cells and serum interleukin (IL)-2 contents. 300 1-day-old avian broilers were divided into four groups and fed on a corn-soybean basal diet as control diet or the same diet amended to contain 500; 1,000; and 1,500 mg/kg of Mo supplied as sodium molybdate dihydrate. In comparison with those of the control group, the percentages of CD3(+), CD3(+)CD4(+) and CD3(+)CD8(+) were decreased in 1,000 and 1,500 mg/kg of Mo intake groups from 14 days of age to 42 days of age. Also, the serum IL-2 contents were decreased in 1,000 and 1,500 mg/kg of Mo intake groups from 14 days of age to 42 days of age. Histopathologically, hypocellularity appeared in the thymus in 1,000 and 1,500 mg/kg of Mo intake groups. It was concluded that dietary high-Mo (1,000 mg/kg and 1,500 mg/kg) reduced the percentages of peripheral blood T-cell subsets and serum IL-2 contents and caused thymic lesions. The cellular immune function was finally injured in broilers.

References

Nov 1, 1981·The American Journal of Clinical Nutrition·N N AbumradL S Rogers
May 16, 2002·The British Journal of Nutrition·Maxine BonhamJ J Strain
Mar 22, 2006·The Journal of Nutrition·Janet A Novotny, Judith R Turnlund
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Jul 10, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vitaly V GanusovRob J De Boer
Apr 12, 2008·Acta Veterinaria Hungarica·András BersényiSándor György Fekete

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Citations

Feb 19, 2015·Toxicology and Industrial Health·Hong-Wei WangEr-Jie Tian
Jan 10, 2021·Ecotoxicology and Environmental Safety·Aimin JiangZhengkai Wei

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