Effect of dietary honey on intestinal microflora and toxicity of mycotoxins in mice

BMC Complementary and Alternative Medicine
Aly M Ezz El-ArabAzzat B Abd El-Khalek

Abstract

Bee honey is a functional food which has a unique composition, antimicrobial properties and bifidogenic effect. In order to assess whether honey can inhibit the toxic effect of mycotoxins, the present study was undertaken. Production of biomass and toxins by Aspergillus parasiticus and Aspergillus ochraceus were followed in media without and with honey. Although aflatoxins and ochratoxin A. were administrated to male Swiss albino mice up to 1 mug and 10 ng/kg body weight/day respectively. The experimental animals were fed diets without our with 10% honey for two months. The changes in colonic probiotic bacteria, determintal colon enzyme glucuronidases, and genotoxicity were followed. Addition of 32% in its media increased the biomass of A parasiticus, while the biomass of A. ochraceus decreased and Ochratoxin A. was not produced. When the honey was added at the ratio of 32 and 48% in the medium. No relationship was found between mycelium weight and production of mycotoxins. Oral administration of aflatoxins (mixture of B1, B2, G1 and G2) and Ochratoxin A. induced structural and numerical chromosomal aberrations in bone marrow and germ cells of male mice, whereas, honey treatment reduced the genotoxicity of mycotoxins. Also both...Continue Reading

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Citations

Jul 20, 2012·International Journal of Biological Sciences·Omotayo O ErejuwaMohd S Ab Wahab
Jun 26, 2015·Toxins·Eduardo Madrigal-BujaidarEduardo Madrigal-Santillán
Oct 4, 2011·Disability and Rehabilitation·Catherine A OkoroLina S Balluz
May 12, 2016·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Courtney BoydUNKNOWN Evidence for Massage Therapy (EMT) Working Group
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Mar 19, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Li JiangXiaoxiong Zeng
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Methods Mentioned

BETA
chromosomal aberrations

Software Mentioned

SAS

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