Effect of dietary lysine level and protein restriction on the lipids and carnitine levels in the liver of pregnant rats

Annals of Nutrition & Metabolism
M F Fernández Ortega

Abstract

Carnitine, biosynthesized from the essential amino acid lysine, has been considered as the shuttling of long-chain fatty acid acyl residues into the matrix of mitochondria for beta-oxidation. This lysine-carnitine relation was studied in pregnant rats nourished with diets differing in lysine and protein content. Pregnancy seems to be a factor contributing to the increase of the free carnitine fraction and phospholipids in the liver, whatever the diet allowed. In the case of nonpregnant rats, free carnitine levels decrease and triglycerides increase in the liver when they are nourished with a low-protein and lysine-deficient diet.

Citations

Jan 28, 2006·The Journal of Membrane Biology·P García-MirandaA A Ilundáin
Jan 23, 2002·The Biochemical Journal·Frédéric M Vaz, Ronald J A Wanders
May 1, 2013·Critical Reviews in Food Science and Nutrition·Anthony Fardet, Jean-Michel Chardigny
Jul 17, 2003·Journal of Animal Physiology and Animal Nutrition·C Brandsch, K Eder
Jul 18, 2018·Journal of Agricultural and Food Chemistry·Luigi ServilloMaria Luisa Balestrieri

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