Effect of dietary n-3 fatty acids on hypoxia-induced necrotizing enterocolitis in young mice. n-3 fatty acids alter platelet-activating factor and leukotriene B4 production in the intestine

Biology of the Neonate
Mete AkisuAfig Huseyinov

Abstract

Necrotizing entercolitis (NEC) is an important neonatal disease with a high mortality rate. Inflammatory mediators, such as mainly platelet-activating factor (PAF), leukotrienes (LT) and tumor necrosis factor play an important role in the genesis of NEC. Diets in omega-3 (n-3) fatty acids appear to have an antiinflammatory effect, which is thought to be due to decreased active prostaglandins and leukotrienes production after incorporation of these fatty acids into cell membrane phospholipids. We investigated the protective effect of fish oil (source of n-3 fatty acids) on hypoxia-induced model of NEC. Young mice were divided into three groups; group 1 mice were fed standard chow (n-3 fatty acids-free), group 2 was fed a chow supplemented by 10% fish oil for 4 weeks. Group 3 mice served as control. We examined the intestinal lesions by light microscopy and measured intestinal tissue PAF and LB4 levels in hypoxia-induced model of NEC. Significantly increased intestinal PAF and LTB4 levels were found in group 1 mice when compared to group 2 and group 3 mice. The histopathology of the intestinal lesions in group 1 animals was characteristic of ischemic injury. In the n-3 fatty acids-supplemented animals these lesions were milder. T...Continue Reading

Citations

Feb 17, 2001·The Journal of Nutritional Biochemistry·J E. Teitelbaum, W Allan Walker
Jul 24, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Christine F Coursodon-BoyiddleBohuslav Dvorak
Feb 8, 2005·Pediatrics International : Official Journal of the Japan Pediatric Society·Ceyda KabarogluOya Bayindir
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Dec 30, 2020·Prostaglandins, Leukotrienes, and Essential Fatty Acids·E FragopoulouS Antonopoulou
Feb 18, 2019·Clinics in Perinatology·Brandy L Frost, Michael S Caplan
Mar 29, 2002·Clinics in Perinatology·Douglas G Burrin, Barbara Stoll

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