Effect of dietary n-3/n-6 fatty acid ratio on the total count, fatty acid composition, and histamine and leukotriene concentrations of mast cells in tunica mucosa bronchiorum of type I allergic guinea pig

Bioscience, Biotechnology, and Biochemistry
M KuwamoriS Innami

Abstract

To search for the most effective dietary n-3/n-6 ratio to suppress the type I allergic response, we performed basic experiments that applied parameters, associated with the type I allergy. Guinea pigs fed on diets containing lipids with the n-3/n-6 ratio at different levels and the polyunsaturated fatty acid/saturated fatty acid ratio of a fixed level were sensitized with ovalbumin and reared for two weeks. The lowest or critical level of the n-3/n-6 ratio which produced a significant difference in the parameters was as follows: about 2.0 for the response of mast cells and eosinophils; 0.5 and 1.0, respectively, for the uptake of n-3 and n-6 polyunsaturated fatty acids and decreased histamine production; and 0.2 for decreased leukotriene B4 and total leukotrienes 4, and increased leukotrienes 5/leukotrienes 4. The critical level of the n-3/n-6 ratio thus differed widely according to the parameter. Overall, the upper limit for the dietary n-3/n-6 ratio to suppress antigen-induced type I allergic responses is suggested to be around 1.0.

Citations

May 16, 2012·Advances in Nutrition·Pedro Luis Prior, José Carlos Fernandes Galduróz
Nov 13, 2008·Journal of Oleo Science·Hiroyuki TakeuchiToshiaki Aoyama
Mar 15, 2015·Journal of Leukocyte Biology·Xiaofeng Wang, Marianna Kulka
Jun 11, 2019·Frontiers in Immunology·Tamara HoppenbrouwersLinette E M Willemsen
May 21, 2020·Frontiers in Immunology·Tamara HoppenbrouwersHarry J Wichers
Feb 7, 2002·Journal of Agricultural and Food Chemistry·Si-Yin ChungDaniel W Gorbet

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