Effect of dietary nitrate supplementation on metabolic rate during rest and exercise in human: A systematic review and a meta-analysis

Nitric Oxide : Biology and Chemistry
Mehdi Pawlak-ChaouchJulien Aucouturier

Abstract

Recent randomized controlled trials have suggested that dietary nitrate (NO3(-)), found in beetroot and other vegetables, and inorganic NO3(-) salts decrease metabolic rate under resting and exercise conditions. Our aim was therefore to determine from a systematic review and meta-analysis whether dietary NO3(-) supplementation significantly reduces metabolic rate, expressed as oxygen uptake (VO2), under resting and exercise conditions in healthy humans and those with cardiorespiratory diseases. A systematic article search was performed on electronic databases (PubMed, Scopus and Web of Science) from February to March 2015. The inclusion criteria included 1) randomized controlled trials; 2) studies reporting the effect of NO3(-) on VO2 under resting and/or exercise conditions; 3) comparison between dietary NO3(-) supplementation and placebo. Random-effects models were used to calculate the pooled effect size. Twenty nine randomized placebo-controlled trials were included in the systematic review, and 26 of which were included in the meta-analysis. Dietary NO3(-) supplementation significantly decreases VO2 during submaximal intensity exercise [-0.26 (95% IC: -0.38, -0.15), p < 0.01], but not in the sub-analysis of subjects with c...Continue Reading

References

Jan 1, 1996·American Journal of Respiratory and Critical Care Medicine·F MaltaisP LeBlanc
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Aug 25, 2000·European Journal of Applied Physiology·J A NederB J Whipp
Apr 28, 2005·The Journal of Experimental Biology·Ewald R Weibel, Hans Hoppeler
Apr 21, 2007·Journal of Bioenergetics and Biomembranes·Pascaline ClercEric Fontaine
Jul 20, 2007·Acta Physiologica·F J LarsenB Ekblom
Nov 1, 2007·Proceedings of the National Academy of Sciences of the United States of America·S C ErzurumC M Beall
Jan 3, 2008·Nature Reviews. Drug Discovery·Jon O LundbergMark T Gladwin
Sep 17, 2008·Nitric Oxide : Biology and Chemistry·Mirco GovoniJon O Lundberg
Oct 1, 2009·Nitric Oxide : Biology and Chemistry·Sruti Shiva
Nov 17, 2009·Free Radical Biology & Medicine·Filip J LarsenBjörn Ekblom
Apr 17, 2010·Science·Luigi FontanaValter D Longo
May 15, 2010·Journal of Applied Physiology·Stephen J BaileyAndrew M Jones
Aug 13, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Anni VanhataloAndrew M Jones
Nov 13, 2010·Journal of Applied Physiology·Katherine E LansleyAndrew M Jones
Feb 3, 2011·Cell Metabolism·Filip J LarsenEddie Weitzberg
Apr 2, 2011·Journal of Applied Physiology·Aarti A KenjaleJason D Allen
Apr 8, 2011·Medicine and Science in Sports and Exercise·Katherine E LansleyAndrew M Jones
May 18, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Filip J LarsenJon O Lundberg
Oct 20, 2011·BMJ : British Medical Journal·Julian P T HigginsUNKNOWN Cochrane Statistical Methods Group
Nov 22, 2011·American Journal of Physiology. Heart and Circulatory Physiology·David C PooleTimothy I Musch
Nov 30, 2011·Experimental Physiology·Markus Amann
Apr 25, 2012·European Journal of Applied Physiology·Daryl P WilkersonAndrew M Jones
Jun 22, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Patrick C Even, Nachiket A Nadkarni
Jul 10, 2012·Journal of Applied Physiology·Evi MasscheleinPeter Hespel
Aug 10, 2012·Medicine and Science in Sports and Exercise·Oliver PeacockOyvind Sandbakk
Nov 24, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·James KellyAndrew M Jones
May 4, 2013·Journal of Applied Physiology·Lee J WylieAndrew M Jones
Jun 29, 2013·Free Radical Biology & Medicine·Shanti VelmuruganAmrita Ahluwalia
Oct 4, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brynmor C BreeseAndrew M Jones
Jan 7, 2014·Respiratory Physiology & Neurobiology·Kevin G ThompsonAndrew M Jones
Jan 31, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Vernon BondGeorges E Haddad
Feb 7, 2014·The American Journal of Clinical Nutrition·Filip J LarsenEddie Weitzberg
May 2, 2014·Medicine and Science in Sports and Exercise·Robert K BoorsmaLawrence L Spriet
Dec 24, 2014·Nitric Oxide : Biology and Chemistry·Conor P KerleyLiam Cormican

❮ Previous
Next ❯

Citations

Dec 7, 2017·High Altitude Medicine & Biology·Alexander PatricianErika Schagatay
Nov 2, 2017·International Journal of Sport Nutrition and Exercise Metabolism·Matthew J BarlowAngelica Lodin-Sundstrom
Aug 22, 2018·Annual Review of Nutrition·Andrew M JonesAnni Vanhatalo
Jul 13, 2018·Exercise and Sport Sciences Reviews·Andrew R Coggan, Linda R Peterson
Jun 1, 2019·International Journal of Food Sciences and Nutrition·Colin R CarrikerAlvaro N Gurovich
Aug 24, 2017·Current Opinion in Clinical Nutrition and Metabolic Care·Conor P Kerley
Jul 28, 2020·Critical Reviews in Food Science and Nutrition·Daniel Rojas-ValverdeBraulio Sanchez-Urena
Jan 10, 2018·Journal of the International Society of Sports Nutrition·Raúl DomínguezManuel Vicente Garnacho-Castaño
May 16, 2019·Journal of the American College of Nutrition·Mehdi Pawlak-ChaouchJulien Aucouturier
Sep 17, 2020·Medicine and Science in Sports and Exercise·Jonathon W SenefeldMichael J Joyner
Mar 3, 2017·European Journal of Applied Physiology·Oliver Michael ShannonJohn Paul O'Hara
Oct 9, 2020·Journal of Applied Physiology·Harald EnganErika Schagatay
Aug 1, 2020·Medicine and Science in Sports and Exercise·Andrew M JonesKristin L Jonvik
Oct 28, 2020·European Journal of Applied Physiology·Daniel A Baur, Michael J Saunders

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.