Effect of dietary Polyphenon E and EGCG on lung tumorigenesis in A/J Mice.

Pharmaceutical Research
Qi ZhangMing You

Abstract

To compare the chemopreventive efficacy of Polyphenon E (Poly E), (-)-epigallocatechin-3-gallate (EGCG) and Polyphenon E without EGCG (Poly E-EGCG) on the development of benzo(a)pyrene (B(a)P)-induced lung tumors in A/J mice. Female A/J mice were given a single intraperitoneal injection of B(a)P (100 mg/kg body weight). One week after B(a)P injection, animals received AIN-76A purified powder diet containing 0.975% (wt/wt) EGCG, 0.525% (wt/wt) Poly E-EGCG or 1.5% (wt/wt) Poly E for 24 weeks or control diet with no additives. Poly E treatment significantly decreased tumor multiplicity by 52% and tumor load by 64%, while EGCG and Poly E-EGCG did not significantly inhibit lung tumor multiplicity. EGCG was more stable in a complex mixture (Poly E) than as a pure compound. EGCG was ineffective when administered by diet likely due to its instability. Thus, EGCG's efficacy on mice lung tumorigenesis requires the presence of other tea catechins.

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Citations

May 6, 2015·Seminars in Cancer Biology·Ramzi M MohammadAsfar S Azmi
Mar 15, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chung S YangHuanyu Jin
May 4, 2011·Molecular Nutrition & Food Research·Axel H Schönthal
May 4, 2011·Molecular Nutrition & Food Research·Chung S Yang, Hong Wang
Feb 24, 2015·Life Sciences·S CyboranH Kleszczyńska
Mar 24, 2018·Nutrition and Cancer·Sunil Kumar DhatwaliaDevinder K Dhawan
Apr 26, 2012·Integrative Cancer Therapies·Heidi FritzDean Fergusson
Jan 13, 2018·Biological Procedures Online·Lijing JiaoLing Xu
Mar 10, 2012·Cancer Prevention Research·Qi ZhangMing You
Sep 24, 2014·Cancer Prevention Research·Jing PanMing You

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