Effect of dietary protein on hepatic and extrahepatic phase I and phase II drug metabolizing enzymes

Toxicology Letters
P K Baijal, D W Fitzpatrick

Abstract

Weanling male rats were fed low (LP, 7.5%), standard (SP, 15%) or high protein (HP, 45%) diet for 7 or 14 days ad libitum, and cytochrome c reductase (CYC) and UDP-glucuronosyltransferase (UGT) enzyme activities were determined in intestine, kidney and liver microsomes. HP diet increased CYC activity in intestine and kidney, while LP diet had no effect. Hepatic CYC activity declined with decreasing level of dietary protein. Liver and intestine UGT activities were higher on an LP diet, while kidney enzyme activities were higher on an HP diet. UGT activity toward alpha-naphthol, a UGT1 isoform substrate, was modulated by dietary protein in all tissues, while UGT activity toward 4-hydroxybiphenyl, a substrate for a second UGT1 isoform, was affected only in the intestine. The duration of feeding affected CYC and UGT activities in the intestine. This observation may be explained by the dynamic nature of intestinal tissue. The observation of unique tissue and enzyme responses suggests that generalizations regarding metabolic response to diets based on hepatic studies or single enzymes, may be erroneous.

References

Dec 1, 1979·Environmental Health Perspectives·H P HoenschF Hartmann
Mar 1, 1992·The Journal of Nutrition·J A OlsonB Shane
Jan 1, 1991·Critical Reviews in Biotechnology·D J Hardman
Dec 1, 1990·Toxicology Letters·V A Catania, M C Carrillo
Apr 1, 1990·Toxicology Letters·A PandeyD W Fitzpatrick
Nov 1, 1988·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·T TephlyY Irshaid
Jan 1, 1988·Pharmacology & Therapeutics·C S Yang, J S Yoo
Jan 1, 1987·Physiology & Behavior·B A SemonD W Gietzen
Mar 15, 1974·Experimental Cell Research·S V Jakobsson
Dec 1, 1970·The Journal of Pharmacy and Pharmacology·G C Wood, B G Woodcock
May 1, 1972·Archives of Biochemistry and Biophysics·A EllinS Orrenius
Nov 1, 1970·Journal of Agricultural and Food Chemistry·E M Boyd, V Krupa
Nov 1, 1983·The Journal of Nutrition·R W Swick, C L Gribskov
Jan 1, 1981·Annual Review of Nutrition·D V Parke, C Ioannides

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Citations

Aug 1, 1997·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P K BaijalR P Bird
Aug 4, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·P K BaijalR P Bird
Jul 25, 2003·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Klaus PissowotzkiDieter Müller

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