PMID: 6778977Jan 1, 1981Paper

Effect of dietary quality of protein on liver microsomal mixed function oxidase system, plasma cholesterol and urinary ascorbic acid in rats fed PCB

The Journal of Nutrition
N KatoA Yoshida

Abstract

Exposure of rat to polychlorinated biphenyls (PCB) results in an increase in activity of liver microsomal mixed function oxidase system, plasma cholesterol and urinary ascorbic acid. Experiments were designed to study the effect of dietary quality of protein on these metabolic responses to dietary addition of PCB. The diets contained either whole egg protein, casein, fish protein, soy protein, soy protein plus 0.34% methionine, wheat-gluten, corn-gluten or gelatin fed at 10% of the diet. In general, the relative biological values of proteins as shown by the gains in body weight were positively correlated with activity of the microsomal enzyme system including aminopyrine N-demethylase, aniline hydroxylase, cytochrome P-450 and NADPH-cytochrome c reductase, plasma level of cholesterol and urinary ascorbic acid. Supplement of methionine to soy protein diet containing PCB caused a significant increase in liver and plasma cholesterol and in urinary ascorbic acid, although the influence on the microsomal enzyme system was slight. The gelatin diet containing PCB gave higher activity of the enzyme system than that expected from the biological value, although the same protein diet without PCB caused quite low activity as expected from ...Continue Reading

Citations

May 1, 1984·Bulletin of Environmental Contamination and Toxicology·S R TyagiU K Misra
Dec 1, 1985·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·S R TyagiU K Misra
Oct 15, 1996·Environmental Toxicology and Pharmacology·R Walker
Jan 1, 1991·Comparative Biochemistry and Physiology. A, Comparative Physiology·K Takahashi, M Horiguchi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Landau-Kleffner Syndrome

Landau Kleffner syndrome (LKS), also called infantile acquired aphasia, acquired epileptic aphasia, or aphasia with convulsive disorder, is a rare childhood neurological syndrome characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electroencephalogram. Discover the latest research on LKS here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.