Effect of dietary quercetin and sphingomyelin on intestinal nutrient absorption and animal growth

The British Journal of Nutrition
J BarrenetxeE Urdaneta

Abstract

Research on cancer and other conditions has shown flavonoids and sphingolipids to be food components capable of exerting chemoprotective action. Nevertheless, little is known about their effects on healthy individuals and their potential usefulness as therapeutic agents. The present study examined the possible action of a dietary flavonoid, quercetin, and a sphingolipid, sphingomyelin, as functional foods in healthy animals. In particular, the effect on animal growth of supplementing a conventional diet with one or other of these substances (0.5 % quercetin and 0.05 % sphingomyelin) was considered. Possible action affecting intestinal physiology was also analysed by measuring the uptake of sugar and dipeptide, mediated by the Na(+)-dependent sugar transporter SGLT1 and the dipeptide Na(+)/H(+) exchanger PEPT1 respectively, and the activity of related intestinal enzymes such as sucrase, maltase and aminopeptidase N. Both substances seemed to modify small intestinal activity in healthy mice, altering intestinal enzymatic activity and nutrient uptake. These effects observed in the small intestine did not impair normal development of the animals, as no differences in serum biochemical parameters or in organ and body weights were fo...Continue Reading

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Citations

May 18, 2011·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Amy M KnabDavid C Nieman
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Jul 14, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Shinta Ayu NurfaradillaYahdiana Harahap
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Aug 6, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Shinta Ayu NurfaradillaYahdiana Harahap
Jul 3, 2021·Journal of Basic and Clinical Physiology and Pharmacology·Tuhfatul UlyaJunaidi Khotib

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