Effect of dietary urea on blood pressure in spontaneously hypertensive rats

Clinical and Experimental Pharmacology & Physiology
H WangY Yamori

Abstract

The feeding of a normal diet containing 13.5% urea (in place of protein in a high protein diet) attenuated the development of severe hypertension and decreased the incidence of stroke in spontaneously hypertensive rats (SHR), when 1% NaCl solution was given to them. The urea not only increased urine volume, but also increased urinary sodium excretion in SHR given 1% NaCl for drinking. Although there was no obvious difference in erythrocyte size between the urea and the control groups, there was a significant inverse correlation between plasma urea level and erythrocyte size. These results suggest that a high protein diet reduced blood pressure partly through the diuretic effect of urea, the common metabolite of various proteins.

References

Jan 1, 1978·Biochemical Pharmacology·Y NaraW Lovenberg
Jul 1, 1977·Japanese Heart Journal·Y YamoriM Ohtaka
May 1, 1957·The Journal of Clinical Investigation·F H EPSTEINA HENDRIKX

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Citations

Jan 1, 1990·Clinical and Experimental Hypertension. Part A, Theory and Practice·Y Yamori
Nov 27, 2007·Autonomic Neuroscience : Basic & Clinical·Nikolai D Temnyalov
Jul 24, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Sachiyo IwataMitsuhiro Yokoyama
Nov 1, 1994·Clinical and Experimental Pharmacology & Physiology·O G GutierrezY Yamori
Mar 15, 1993·Annals of the New York Academy of Sciences·Y Yamori
Mar 1, 1985·Clinical and Experimental Pharmacology & Physiology·H WangY Yamori
Nov 1, 1989·Acta Pathologica Japonica·Y Yamori
Mar 16, 2002·Journal of Human Hypertension·M CirilloUNKNOWN Gubbio Study Research Group
Nov 28, 2002·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Longjian LiuYukio Yamori

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