Effect of dietary vitamin C on compression injury of the spinal cord in a rat mutant unable to synthesize ascorbic acid and its correlation with that of vitamin E

Spinal Cord
D KatohK Fukuzawa

Abstract

The roles of vitamin C on secondary pathological changes after spinal cord injury were investigated by evaluating the effects of dietary vitamin C on experimental spinal cord injury in a mutant strain of Wistar rats unable to synthesize ascorbic acid (ODS rats). Two groups of ODS rats were given vitamin C-deficient or vitamin C-supplemented diet for 1 week before injury. Motor disturbance induced by spinal cord injury was found to be greater in the vitamin C-deficient group. Histologically, the area of bleeding in the spinal cord was also greater in the vitamin C-deficient group. The levels of ascorbic acid and alpha-tocopherol in the spinal cord tissue and serum decreased during and after compression injury of the spinal cord. The decrease of alpha-tocopherol was similar in the two groups. However, the decrease of ascorbic acid was greater in the vitamin C-supplemented group. These results indicated that their protective effects against spinal cord injury are through scavenging water-soluble free radicals by vitamin C and lipid-soluble by vitamin E, and the effects of these vitamins were suggested to be independent.

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Sep 1, 1978·Stroke; a Journal of Cerebral Circulation·E S FlammJ Ransohoff
Jul 1, 1976·Lipids·S L TaylorA L Tappel
Sep 30, 1975·Annals of the New York Academy of Sciences·I B ChatterjeeN Subramanian
Jun 1, 1990·Journal of Nutritional Science and Vitaminology·Y TaokaK Fukuzawa
Jan 1, 1985·Central Nervous System Trauma : Journal of the American Paralysis Association·J M BraughlerR L Chase
Jan 1, 1986·Central Nervous System Trauma : Journal of the American Paralysis Association·E D Hall, J M Braughler
Dec 1, 1985·The Journal of Nutrition·F HorioY Hayashi
Oct 1, 1983·Journal of Neurochemistry·D D PietronigroE S Flamm
Apr 15, 1984·Experientia·Y MizushimaS Makino

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Citations

Nov 10, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Asirvatham Alwin RobertSultan Al Mubarak
May 18, 2000·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·A GörgülüS Cobanoğlu
Aug 3, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Stefan Klussmann, Ana Martin-Villalba
Jul 22, 2014·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Martin M MortazaviR Shane Tubbs
Sep 3, 2013·Experimental Gerontology·Keith C DeRuisseauRobert P Doyle
Dec 3, 1999·Journal of Neurochemistry·Y SagaraJ Chang

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