Effect of dieting on plasma leptin, soluble leptin receptor, adiponectin and resistin levels in healthy volunteers

Clinical Endocrinology
Barbara E WolfeChristos S Mantzoros

Abstract

Recent findings demonstrating important effects of the adipokines on metabolism, energy homeostasis and body weight regulation have prompted research on the possible role of negative energy balance in altering adipocytokine regulation. The goal of this study was to evaluate the effects of a hypocaloric diet in healthy normal-weight volunteers. An additional goal was to help clarify the contribution of restricted caloric intake to altered plasma adipokine levels in the eating disorders anorexia nervosa and bulimia nervosa. Participants were studied before and after a 4-week reduced-calorie diet (1000-12000 kcal/day). patients Subjects included 15 healthy, normal-weight women (age 22 +/- 3 years). Plasma concentrations of leptin, soluble leptin receptor protein (sOB-R), adiponectin, resistin, thyroid hormones and beta-hydroxybutyrate were determined following overnight fast before and after the 4-week reduced-calorie diet. Subjects lost a mean of 3.4 +/- 2.1 kg in response to the reduced-calorie diet. The weight loss phase was associated with a 60.3% decrease in plasma leptin levels (P < 0.001), a 43.5% increase in sOB-R levels (P < 0.002) and a 16.2% decrease in plasma adiponectin levels (P < 0.04). There was no significant chan...Continue Reading

References

Dec 16, 1995·Lancet·J HebebrandW Herzog
Jul 18, 1996·Nature·R S AhimaJ S Flier
Mar 27, 1999·Biochemical and Biophysical Research Communications·Y AritaY Matsuzawa
Jan 5, 2000·The American Journal of Psychiatry·D A Lewis
Jun 10, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·K HottaY Matsuzawa
Aug 12, 2000·Psychoneuroendocrinology·T D BrewertonW T Garvey
Mar 30, 2001·The Journal of Biological Chemistry·K H KimH S Sul
May 15, 2001·Biochemical and Biophysical Research Communications·A LammertJ Kratzsch
Oct 5, 2002·The Journal of Clinical Endocrinology and Metabolism·J KratzschW Kiess
Dec 20, 2002·Endocrine Research·Jarmila KrizovaMartin Haluzik
Jan 10, 2003·Clinical Endocrinology·M L DelporteM Lambert
Mar 4, 2003·European Journal of Endocrinology·Juan J Díez, Pedro Iglesias
Apr 8, 2003·The Journal of Clinical Endocrinology and Metabolism·Nicola PannacciulliGiovanni De Pergola
Jun 6, 2003·The Journal of Clinical Endocrinology and Metabolism·Alina GavrilaChristos S Mantzoros
Aug 15, 2003·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A S RyanD Elahi
Sep 16, 2003·Obesity Research·Lais U MonzilloChristos S Mantzoros
Oct 1, 2003·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·H IwahashiY Matsuzawa

❮ Previous
Next ❯

Citations

Apr 10, 1999·Clinical Endocrinology·C S Mantzoros, S J Moschos
May 31, 2008·Metabolic Syndrome and Related Disorders·Michael M Swarbrick, Peter J Havel
Apr 27, 2010·Diabetes, Obesity & Metabolism·Stergios A PolyzosEleni Tsiaousi
May 19, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Pascal Imbeault
Jul 28, 2011·American Journal of Physiology. Endocrinology and Metabolism·Christos S MantzorosAnastasia Koniaris
Sep 16, 2011·The Journal of Clinical Endocrinology and Metabolism·Vasiliki A MoragianniChristos S Mantzoros
May 9, 2012·The Journal of Clinical Endocrinology and Metabolism·Konstantinos N AronisChristos S Mantzoros
Mar 8, 2007·PLoS Medicine·Anthony E CivitareseUNKNOWN CALERIE Pennington Team
Jan 16, 2007·European Journal of Endocrinology·I PantsulaiaE Kobyliansky
Oct 31, 2013·Reviews in Endocrine & Metabolic Disorders·Bonggi Lee, Jianhua Shao
May 31, 2014·Journal of Exercise Rehabilitation·Sewon Lee, Hyo-Bum Kwak
Oct 5, 2011·Nutrition Reviews·Flávia M SilvaAna M Feoli
May 12, 2009·Journal of Gastroenterology·Takako Eguchi NakajimaYasuhiro Shimada
Aug 21, 2009·Journal of Cancer Research and Clinical Oncology·Takako Eguchi NakajimaYasuhiro Shimada
Sep 25, 2012·Metabolism: Clinical and Experimental·Konstantinos MichalakisDimitrios G Goulis
Apr 13, 2010·The American Journal of Cardiology·Andreia BioloFlora Sam
Jun 6, 2009·Physiology & Behavior·Claus VögeleBrunna Tuschen-Caffier
Dec 15, 2015·Journal of Endocrinological Investigation·X Huang, Z Yang
May 19, 2007·Medical Hypotheses·C J Behre
Jun 5, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Edouard GhanassiaEric Raynaud
Dec 13, 2006·Metabolism: Clinical and Experimental·Christina Nogueira AragãoCarmen Cabanelas Pazos-Moura
Sep 13, 2008·American Journal of Human Biology : the Official Journal of the Human Biology Council·Ia PantsulaiaGregory Livshits
Feb 15, 2012·The International Journal of Eating Disorders·Sara E TraceCynthia M Bulik
Feb 1, 2011·Annals of the New York Academy of Sciences·Yingfeng Deng, Philipp E Scherer
Sep 2, 2009·The International Journal of Eating Disorders·David C JimersonPamela K Keel
Sep 13, 2016·Adipocyte·Erica L SchellerWilliam P Cawthorn
Aug 8, 2006·Nutrition·Ivana DostalovaJara Nedvidkova
Apr 19, 2006·Endocrine Journal·Teruhiko KondoMasami Murakami
May 23, 2015·Metabolism: Clinical and Experimental·Ayse Sahin-EfeChristos S Mantzoros
Dec 4, 2014·Metabolism: Clinical and Experimental·Stergios A Polyzos, Christos S Mantzoros
Dec 17, 2014·Metabolism: Clinical and Experimental·Matthias Blüher, Christos S Mantzoros
Dec 17, 2014·Metabolism: Clinical and Experimental·Jagriti UpadhyayChristos S Mantzoros
Jul 12, 2011·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Soma Sherif Abd El GawadAshraf A Omar
Sep 11, 2013·Journal of Sports Sciences·Chung Bing YangTe Hung Tsao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anorexia Nervosa

Anorexia nervosa (AN) is a psychiatric condition characterized by severe weight loss and secondary problems associated with malnutrition. Here is the latest research on AN.