PMID: 3747735Jul 1, 1986Paper

Effect of different acids with delta 9,12-dienoic structures on delta 9 desaturation activity in rat liver microsomes

Lipids
M J de AlanizR R Brenner

Abstract

The effect of oral administration, for 24 or 48 hr, of different octadeca fatty acids containing a 9,12-dienoic structure on the fatty acid composition and delta 9 desaturation activity of liver microsomes of rat fed a fat-free diet was studied. The ethyl esters of linoelaidic and gamma-linolenic acids, the methyl ester of linoleic acid and free columbinic acid were administered to rats maintained on a fat-free diet. The supplementation of the fat-free diet with linoelaidate produced no relevant changes in the fatty acid composition pattern of liver microsomes and did not modify the percentage of conversion of palmitic to palmitoleic acid. The addition of linoleate or gamma-linolenate to the fat-free diet returned liver microsome delta 9 desaturation activity toward the control and partially restored the liver microsome fatty acid spectrum found in the fat-free diet. Columbinic acid (5-trans-9-cis,12-cis-18:3), which cannot be transformed into arachidonic acid, also decreased the delta 9 desaturation activity enhanced by the fat-free diet and evoked changes in the microsomal fatty acid composition similar to those produced by the omega 6 fatty acids. These results suggest that the modulation of delta 9 desaturase activity evoke...Continue Reading

References

Jan 1, 1978·FEBS Letters·R Jeffcoat, A T James
Oct 25, 1978·Biochimica Et Biophysica Acta·R I Karney, G A Dhopeshwarkar
Apr 1, 1972·Archives of Biochemistry and Biophysics·N Oshino, R Sato
Mar 8, 1974·Molecular and Cellular Biochemistry·R R Brenner
Jul 1, 1970·Lipids·J R PaulsrudR T Holman
Jul 1, 1967·The Journal of Nutrition·O S PrivettE C Nickell
Sep 1, 1984·Molecular and Cellular Biochemistry·M J de AlanizR R Brenner
Jan 1, 1981·Progress in Lipid Research·H Sprecher
Jan 1, 1981·Progress in Lipid Research·U M Houtsmuller

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Citations

Oct 15, 1991·Biochimica Et Biophysica Acta·P Legrand, A Bensadoun
Jul 29, 1999·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·F Z HoussaïniP Groslambert
Dec 1, 1993·Journal of the American College of Nutrition·W M RatnayakeG Pelletier

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