PMID: 20646562Jul 22, 2010Paper

Effect of different analgesia combined with low molecular heparin on hemorheology and coagulation in patients undergoing total hip replacement

Zhonghua yi xue za zhi
Xiao-kan Lou, Mei-juan Yan

Abstract

To observe the effect of different analgesia combined with low molecular heparin (LMWH) on hemorheology and coagulation in patients undergoing total hip replacement (THR). Patients undergoing THR with spinal combined epidural anesthesia (SCEA) were randomized to one of four groups: group E(0) received patient-controlled epidural analgesia (PCEA) without LMWH; group E(L) sames but combined with LMWH; group I(0) received patient-controlled intravenous analgesia (PCIA) without LMWH and I(L) the sames but combined with LMWH. Venous blood samples were taken after hospitalization, at the end of operation, 24 h, 48 h and 7 d after operation for determination of hemorheology, indexes of coagulation function. Visual analogue scale (VAS) scores were recorded at 24 h and 48 h postoperation. All the patients received colour Doppler ultrasonography examination before operation, and on the 7th day after operation. Complication of preoperation were recorded. There was no significant change in VAS among the four groups. The rates of DVT occurrence in group I(L) and E(L) were significantly lower than in group I(0) and E(0)(P < 0.05), and there was no significant difference between group I(L) and E(L) or between group I(0) and E(0). The incidenc...Continue Reading

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