PMID: 11906665Mar 22, 2002Paper

Effect of different dose schedules of latanoprost on intraocular pressure and pupil size in the glaucomatous Beagle

Veterinary Ophthalmology
Kirk N Gelatt, Edward O Mackay

Abstract

To evaluate the changes in intraocular pressure and pupil size in glaucomatous dogs after instillation of 0.005% latanoprost (Xalatan, Pharmacia and Upjohn, Kalamazoo, MI, USA) once in the morning, or once in the evening, or twice daily in five-day multiple-dose studies. Animals studied Eight Beagles with the moderate stage of inherited primary open-angle glaucoma. Applanation tonometry (IOP) and pupil size (PS) measurements were obtained at 8 am, 10 am, 12 noon, 2 pm, and 4 pm in eight glaucoma dogs. Methylcellulose (0.5% as placebo) was instilled in the control eye, and 0.005% latanoprost was instilled in the opposite drug eye. Control and drug eyes were selected using a random table. For these three studies, 0.5% methylcellulose and 0.005% latanoprost were instilled the second through the fifth days with instillations in the morning (8.30 am), or evening (8 pm), or twice daily (8.30 am and 8 pm). Statistical comparisons between drug groups included control, placebo, and treated (0.005% latanoprost) eyes for three multiple-dose studies. In the 8-am latanoprost study, the mean +/- SEM diurnal declines in IOP for the placebo and drug eyes for the first day were 6.5 +/- 3.6 mmHg and 8.4 +/- 4.0 mmHg, respectively. The mean +/- S...Continue Reading

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Citations

Jan 23, 2003·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Kirk N Gelatt, Edward O Mackay
Jan 15, 2005·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Kirk N GelattAlison Biken
Apr 27, 2010·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Valentina BorghiFrancesco Impagnatiello
Feb 5, 2008·American Journal of Veterinary Research·Andrew L GrellerAndrás M Komáromy
Nov 6, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hyun Jung JungAnuj Chauhan
Jun 23, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cheng-Chun PengAnuj Chauhan
Sep 1, 2015·The Veterinary Clinics of North America. Small Animal Practice·Anthony F AlarioStefano Pizzirani
Jul 13, 2005·Veterinary Ophthalmology·Joshua T BartoeAlan H Brightman
Feb 25, 2006·Veterinary Ophthalmology·Alex B CarvalhoPatrícia R Silveira
Nov 5, 2011·Veterinary Ophthalmology·Edward O MackayKirk N Gelatt
Dec 12, 2012·Veterinary Ophthalmology·Susan TsaiMichael R Robinson
Jul 18, 2015·Veterinary Ophthalmology·Jessica E McDonaldGillian J McLellan
Sep 18, 2014·Journal of Veterinary Pharmacology and Therapeutics·T Maślanka
Oct 24, 2015·Topics in Companion Animal Medicine·Federica Maggio
Feb 18, 2012·Current Eye Research·Cheng-Chun PengAnuj Chauhan
Jun 26, 2015·American Journal of Veterinary Research·Kyle L TofflemireR David Whitley
Jan 31, 2019·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Susan S LeeMichael R Robinson
Jan 8, 2020·Veterinary Ophthalmology·Vanessa Y YangNoelle C La Croix
Jan 8, 2021·Veterinary Ophthalmology·András M KomáromyShin Ae Park

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