Effect of different doses of aerobic exercise on total white blood cell (WBC) and WBC subfraction number in postmenopausal women: results from DREW.

PloS One
Neil M JohannsenTimothy S Church

Abstract

Elevated total white blood cell (WBC) count is associated with an increased risk of coronary heart disease and death. Aerobic exercise is associated with lower total WBC, neutrophil, and monocyte counts. However, no studies have evaluated the effect of the amount of aerobic exercise (dose) on total WBC and WBC subfraction counts. To examine the effects of 3 different doses of aerobic exercise on changes in total WBC and WBC subfraction counts and independent effects of changes in fitness, adiposity, markers of inflammation (IL-6, TNF-α, C-reactive protein), fasting glucose metabolism, and adiponectin. Data from 390 sedentary, overweight/obese postmenopausal women from the DREW study were used in these analyses. Women were randomized to a non-exercise control group or one of 3 exercise groups: energy expenditure of 4, 8, or 12 kcal kg(-1)⋅week(-1) (KKW) for 6 months at an intensity of 50% VO2peak. A dose-dependent decrease in total WBC counts (trend P = 0.002) was observed with a significant decrease in the 12KKW group (-163.1±140.0 cells/µL; mean±95%CI) compared with the control (138.6±144.7 cells/µL). A similar response was seen in the neutrophil subfraction (trend P = 0.001) with a significant decrease in the 12KKW group (-15...Continue Reading

Associated Clinical Trials

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Citations

Mar 19, 2013·Lipids in Health and Disease·Leandro Pereira de MouraMaria Alice Rostom de Mello
Feb 27, 2016·Heart & Lung : the Journal of Critical Care·Tracy L HammondsJoel W Hughes
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Nov 9, 2021·International Journal of Sports Medicine·Wissal AbassiAnissa Bouassida

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Methods Mentioned

BETA
blood collection
ELISA

Software Mentioned

DREW

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