PMID: 1089446Jan 25, 1975

Effect of different doses of chlorthalidone on blood pressure, serum potassium, and serum urate

British Medical Journal
C BengtssonL Werkö


Chlorthalidone given to 40 hypertensive women significantly decreased blood pressure and serum potassium levels and increased the serum urate concentration. There were no individual correlations between the reduction in blood pressure and the decrease in serum potassium or the increase in serum urate. A reduction in dosage from 50 mg daily to 50 mg three times a week produced no significant changes in the diastolic or mean blood pressures though the systolic blood pressure was moderately increased. Concomitantly, serum potassium increased and serum urate decreased significantly on the lower chlorthalidone dose. We conclude that high doses of oral diuretics compared with lower ones are of limited further benefit and may increase the risk of clinically significant hypokalaemia and hyperuricaemia.


Dec 31, 1959·The New England Journal of Medicine·L A HEALEYJ L DECKER


Jan 1, 1981·European Journal of Clinical Pharmacology·I S SketrisM C Meyer
Oct 1, 1977·Clinical Pharmacology and Therapeutics·B BeermannB Lindström
Jan 1, 1987·European Journal of Clinical Pharmacology·A SalvettiL Papi
Jan 1, 1989·Irish Journal of Medical Science·G D Johnston
Jul 11, 2013·Current Hypertension Reports·George C RoushTheodore R Holford
Jan 1, 1989·Journal of Steroid Biochemistry·M de GasparoJ Ménard
Apr 22, 1976·The New England Journal of Medicine·O B Holland, N M Kaplan
Dec 17, 2009·Cardiology in Review·Kimberly M Neff, James J Nawarskas
Jan 22, 2014·Expert Opinion on Pharmacotherapy·Juan TamargoLuis M Ruilope
Jan 1, 1983·Current Medical Research and Opinion·D B Campbell
Nov 27, 2009·The New England Journal of Medicine·Michael E Ernst, Marvin Moser
Nov 22, 2011·Seminars in Nephrology·Michael E Ernst, Samuel J Mann
Jan 1, 1981·Journal of Chronic Diseases·E H WagnerJ T Warner
Aug 7, 1999·The American Journal of Cardiology·P A Meredith
Aug 1, 1982·American Heart Journal·J J HammondB P Hamilton
Aug 1, 1982·British Journal of Clinical Pharmacology·P R WilkinsonE B Raftery
Dec 1, 1994·Clinical Radiology·G H Ritsema, G Eilers
May 2, 1990·The American Journal of Cardiology·P Aranda, E Lopez de Novales
Jun 1, 1986·Hypertension·P F Magee, E D Freis
Apr 1, 1986·Photochemistry and Photobiology·R G Johnson, R H Haynes
Jan 1, 1979·The Journal of International Medical Research·R BuonincontiM Rubegni
Jan 1, 1984·The Journal of International Medical Research·E L WebbE S Neiss
Jan 1, 1984·Acta Pharmacologica Et Toxicologica·C Bengtsson
May 17, 1978·European Journal of Clinical Pharmacology·B BeermannB Wikland
Mar 3, 1998·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·P A Meredith
Feb 9, 2012·Postgraduate Medicine·David S KountzMayer Ezer
Jan 1, 1979·Acta Medica Scandinavica. Supplementum·C Bengtsson

Related Concepts

Diastolic Blood Pressure
Clinical Trials
Depression, Chemical
Hypertensive Disease

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Related Papers

European Journal of Clinical Pharmacology
J G RussellI S Humphries
Journal of the Renin-angiotensin-aldosterone System : JRAAS
Alun D Hughes
Journal of Pharmaceutical Sciences
H W Murphy
© 2021 Meta ULC. All rights reserved