Effect of different factors on patient perception of surgical discomfort in third molar surgery

Brazilian Oral Research
Giselle Emilãine da Silva ReisRafaela Scariot

Abstract

The aim of this study was to evaluate patient perception of surgical discomfort in third molar surgery and the association with clinical variables and polymorphisms associated with the FKBP5, SLC6A4, and COMT genes. This cross-sectional observational study was carried out on 196 participants aged between 18 and 64 years at the Federal University of Paraná in 11 months. The intensity of surgical discomfort was assessed using the QCirDental questionnaire. Data on surgical and individual procedures were also cataloged. The oral health related quality of life was assessed by the Oral Health Impact Profile questionnaire (OHIP-14). The DNA sample was obtained from cells of the oral mucosa. Five markers of the FKBP5, SLC6A4, and COMT genes were genotyped. The data were submitted to statistical analysis with a significance level of 5%. Women reported greater intensity of discomfort associated with third molar surgery compared to men (p = 0.001). In the recessive model, the AA genotype of the rs3800373 marker was associated with greater surgical discomfort (p = 0.026). Therefore, women and individuals of the AA genotype for the rs3800373 marker in the FKBP5 gene reported greater surgical discomfort associated with third molar surgery.

References

Aug 1, 1997·Community Dentistry and Oral Epidemiology·G D Slade
Mar 3, 1998·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·K M FlegalC L Johnson
Nov 28, 2000·The British Journal of Oral & Maxillofacial Surgery·A G GarcíaM S Martin
Jul 10, 2001·British Dental Journal·T RentonM McGurk
Oct 2, 2001·The American Journal of Psychiatry·J M HettemaK S Kendler
Apr 17, 2004·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Ingibjörg S BenediktsdóttirHanne Hintze
Jul 13, 2005·Community Dentistry and Oral Epidemiology·Branca Heloisa Oliveira, Paulo Nadanovsky
Jul 27, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kent SteningAnders Blomqvist
Sep 22, 2007·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Olalekan Micah GbotolorunAkinola Ladipo Ladeinde
Nov 6, 2007·Brazilian Dental Journal·Marisi Aidar, Sergio Roberto Peres Line
Feb 17, 2009·European Journal of Pain : EJP·Rebecca R KlatzkinSusan S Girdler
Mar 24, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Oladimeji A Akadiri, Ambrose E Obiechina
Apr 21, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Arjen van WijkJerome H Lindeboom
May 5, 2009·The Journal of Pain : Official Journal of the American Pain Society·Roger B FillingimJoseph L Riley
Jan 5, 2011·Medicina oral, patología oral y cirugía bucal·Nelson-Luis Barbosa-RebellatoRafaela Scariot
Jun 26, 2013·British Journal of Anaesthesia·E J Bartley, R B Fillingim
Sep 3, 2013·Journal of Maxillofacial and Oral Surgery·Anisha MariaParag Virang
Sep 17, 2013·Journal of Oral Rehabilitation·D R ReissmannG Heydecke
Aug 31, 2014·Pain·Samah HassanGillian Einstein
Dec 31, 2014·TheScientificWorldJournal·Ricardo Wathson Feitosa de Carvalho, Belmiro Cavalcanti do Egito Vasconcelos
Apr 17, 2015·International Dental Journal·Igor Batista CamargoJoseph E Van Sickels
May 26, 2018·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Lucas Duarte-RodriguesEndi Lanza Galvão
Oct 1, 2018·Pain Practice : the Official Journal of World Institute of Pain·Alba PiroliAntonella Paladini
Oct 3, 2018·Journal of Affective Disorders·Sage E HawnAnanda B Amstadter
Feb 4, 2019·Journal of Affective Disorders·Ali AmadPhilip Gorwood

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Affective Disorders
Ali AmadPhilip Gorwood
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Jane E SarginsonGreer M Murphy
© 2021 Meta ULC. All rights reserved