Effect of different flavonoids on collagen synthesis in human fibroblasts.

Plant Foods for Human Nutrition
Tamara StipcevicD Vanden Berghe

Abstract

In this study, we discovered that flavonoids belonging to the subclasses: (flavanone, flavone, and flavonol) display differential effects on the synthesis of collagen in human dermal fibroblasts. At 80 microg/ml flavonoids quercetin-3,3',4', 5,7-pentahydroxyflavone, 3-methyl quercetin, and 7-hydroxyflavone significantly decreased the total protein concentration which was a direct consequence of their cytotoxic effect, while naringenin exhibited no effect on total collagen and total protein concentration. Quercetin-3,3'4',7-tetramethyl ether, 4'-hydroxyflavanone, flavanone, and fisetin significantly decreased collagen concentration while morin, rutin, and chrysin increased collagen concentration without changing the overall protein concentration. The initial screening performed in this study enables the identification of compounds that exert significant effects on fibroblast function and show potential as starting material for pharmaceutical preparations targeted against various disorders centered around disturbed collagen metabolism.

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Citations

Nov 1, 2012·Biopharmaceutics & Drug Disposition·Tomohide UnoHiromasa Imaishi
Jun 15, 2016·Journal of Ayurveda and Integrative Medicine·Santram LodhiAwesh K Yadav
May 27, 2016·Pharmaceutical Biology·Li ZhuYan-Hua Lu
Jul 1, 2016·Acta Veterinaria Scandinavica·Ramona BabosovaMonika Martiniakova
Jun 2, 2017·Annals of Dermatology·Hannah HongEung Ho Choi
Sep 22, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Oya UstunerUfuk Koca-Caliskan
Feb 13, 2021·International Journal of Molecular Sciences·Indira Putri NegariChun-Ming Huang

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