PMID: 6414235Aug 1, 1983Paper

Effect of different inhibitors on nonspecific alkaline phosphatase in the microsomal fraction from isolated odontoblasts

Acta Odontologica Scandinavica
G Granström

Abstract

In the microsomal fraction isolated from rat incisor odontoblasts, the influence of several inhibitors on p-nitrophenyl phosphatase activity (p-NPPase) was demonstrated at pH 10.3 and compared with the influence at pH 8.8. The inhibiting effect of EDTA on the p-NPPase activity was reversed by equimolar concentrations of Zn2+. The inhibitory effect of three diphosphonates, ethane-1-hydroxydiphosphonate (EHDP), methanediphosphonate (MDP), and dichloromethanediphosphonate (Cl2MDP) was equal to that of a chelating agent. Tetramisole and levamisole exerted an inhibitory effect that was different from the complexing type. L-Cystein, but not L-ascorbic acid, inhibited p-NPPase activity with a maximum inhibitory effect at pH 10.5.

References

May 1, 1978·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·G GranströmH Nygren
Aug 28, 1975·Histochemistry·M Borgers, F Thoné
May 20, 1974·Biochimica Et Biophysica Acta·R Felix, H Fleisch
Aug 1, 1972·Archives of Oral Biology·G Granström, A Linde
Sep 1, 1973·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M Borgers
Oct 14, 1969·Annals of the New York Academy of Sciences·R T Simpson, B L Vallee
Jan 1, 1971·Clinical Orthopaedics and Related Research·J H WöltgensO L Bijvoet
Jan 1, 1970·Calcified Tissue Research·J H WöltgensO L Bijvoet
Jun 1, 1961·The American Journal of Physiology·H FLEISH, W F NEUMAN

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