PMID: 6749774Jul 1, 1982

Effect of different levels of positive end-expiratory pressure on lung water content

Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
J A RussellJ F Murray

Abstract

To compare the effects of 2-, 5-, and 10-cmH2O positive end-expiratory pressure (PEEP) on pulmonary extravascular water volume (PEWV), pulmonary blood volume (PBV), pulmonary dry weight (PDW), and distensibility, we separately ventilated perfused dogs' lungs in situ and produced pulmonary edema with oleic acid (0.06 ml/kg). Three groups were studied: I, PEEP, 5 cmH2O in both lung; II, PEEP, 2 cmH2O in one lung and 10 cmH2O in the other; and III, PEEP, same as II, but the chest was rotated to compensate for differences in heights. The PEWV and distensibility were less (P less than 0.05) in lungs exposed to 10-cmH2O than to either 2- or 5-cmH2O PEEP. After chest rotation, the difference between 10- and 2-cmH2O PEEP on PEWV was eliminated but that on distensibility was not. We conclude that 10-cmH2O PEEP 1) decreased water content because of lung volume-induced effects on intravascular hydrostatic pressure and 2) improved distensibility by recruitment of alveoli, irrespective of PEWV.

References

Aug 1, 1986·Anaesthesia and Intensive Care·D R Hillman
Mar 22, 2018·Critical Care : the Official Journal of the Critical Care Forum·Paolo PelosiMarcelo Gama de Abreu
Feb 19, 1998·Critical Care Medicine·J M Luce
Oct 17, 2015·Journal of Applied Physiology·Gary F NiemanNader Habashi
Nov 1, 1987·Acta Anaesthesiologica Scandinavica·C FrostellC J Wickerts

Related Concepts

Pulmonary Edema
Lung
Positive End-Expiratory Pressure
Lung Compliance
Pulmonary Circulation
Oleate
Body Water
Oleic Acids
Canis familiaris

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