Jun 1, 1967

Effect of different nutritional conditions on the synthesis of tricarboxylic acid cycle enzymes

Journal of Bacteriology
R S Hanson, D P Cox


The effect of various nutritional conditions on the levels of Krebs cycle enzymes in Bacillus subtilis, B. licheniformis, and Escherichia coli was determined. The addition of glutamate, alpha-ketoglutarate, or compounds capable of being catabolized to glutamate, to a minimal glucose medium resulted in complete repression of aconitase in B. subtilis and B. licheniformis. The synthesis of fumarase, succinic dehydrogenase, malic dehydrogenase, and isocitric dehydrogenase was not repressed by these compounds. It is postulated that glutamate or alpha-ketoglutarate is the true corepressor for the repression of aconitase. A rapidly catabolizable carbon source and alpha-ketoglutarate or glutamate must be simultaneously present for complete repression of the formation of aconitase. Conditions which repress the synthesis of aconitase in B. subtilis restrict the flow of carbon in the sequence of reactions leading to alpha-ketoglutarate but do not prevent glutamate oxidation in vivo. The data indicate that separate and independent mechanisms regulate the activity of the anabolic and catabolic reactions of the Krebs cycle in B. subtilis and B. licheniformis. The addition of glutamate to the minimal glucose medium results in the repression o...Continue Reading

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Mentioned in this Paper

Alkalescens-Dispar Group
Enzymes, antithrombotic
Malate Dehydrogenase
Succinate Dehydrogenase
Alpha Ketoglutarate
Reproduction Spores
Catabolic Process
Glucose, (beta-D)-Isomer
Bacillus licheniformis

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