PMID: 9444517Jan 1, 1997Paper

Effect of different ozone concentrations on the neurogenic contraction and relaxation of guinea pig airways

Fundamental & Clinical Pharmacology
B SommerL M Montaño

Abstract

Prejunctional and postjunctional effects of several ozone (O3) concentrations, including those found in highly polluted cities, were evaluated in guinea pig airways. Animals bred in O3-free conditions were exposed to air or O3 (0.3, 0.6 or 1.2 ppm) during 4 h, and studied 16-18 h later. Tracheal and bronchial rings were studied in organ baths. Electrical field stimulation (EFS) (100 V, 2 ms, 10 s) was given at increasing frequencies (0.25-16 Hz). Some tissues received atropine (2 microM) and/or propranolol (10 microM). Concentration-response curves to carbachol, isoproterenol, nitroprusside, and substance P were constructed. In tracheas, almost all O3 concentrations decreased the relaxation at low EFS frequencies, but had no effect on the propranolol-resistant (i-NANC) relaxation, suggesting that only adrenergic relaxation was affected. This was a prejunctional effect, since O3 did not modify the responses to isoproterenol. Relaxation induced by a nitric oxide (NO) donor, nitroprusside, was not affected by O3, which agrees with the lack of O3-effect on i-NANC system. O3 did not modify the EFS-induced e-NANC contraction in atropine-treated bronchi, nor the contraction caused by exogenous substance P. By contrast, in bronchi with...Continue Reading

References

Jul 1, 1992·Journal of Applied Physiology·M G CamposL M Montaño
Dec 1, 1992·The Journal of Allergy and Clinical Immunology·H SalariR R Schellenberg
Jan 1, 1987·Pharmacology & Therapeutics·R G Andersson, N Grundström
Jun 1, 1983·Agents and Actions·E MasiniP F Mannaioni
Jun 1, 1994·Canadian Journal of Physiology and Pharmacology·L J Janssen, S M Sims
Jan 1, 1996·Fundamental & Clinical Pharmacology·A DelaunoisM Ansay
Mar 28, 1996·European Journal of Pharmacology·T TanabeC Inagaki

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Citations

Jun 19, 2001·Journal of Applied Toxicology : JAT·B SommerL M Montaño
Feb 1, 2011·Experimental Physiology·Jaime ChávezLuis M Montaño

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