Effect of different Thai traditional processing of various hot chili peppers on urethane-induced somatic mutation and recombination in Drosophila melanogaster: assessment of the role of glutathione transferase activity

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
P LaohavechvanichA J Ketterman

Abstract

Four different Thai traditional chili peppers, namely bird pepper (Capsicum frutescens), red chili spur peppers (Capsicum annuum), green bell peppers and sweet pepper (C. annuum) were investigated for their antimutagenic properties. Each chili was prepared in three formulations commonly used for chili food processing; raw paste (chili ground in water), pickled in vinegar or stir-fried in palm oil. Each sample was tested for its antimutagenic effect against urethane by using the somatic mutation and recombination of wing hair of Drosophila melanogaster as an indicator. Three-day-old larvae, trans-heterozygous for two genetic markers, multiple wing hairs mwh and orrigon (ORR;flr3), were exposed to urethane alone or in combination with each chili formulation. The various processing methods for chilies differentially extracted the antimutagenic chili components. The specific chili as well as the method of processing influenced the observed antimutagenic properties against urethane. This suggested each chili contains a unique complex mixture of many antimutagens. Co-treatment and pre-treatment experiments showed that both direct and indirect protective mechanisms are involved in an 'activation' process to give antimutagenesis effect...Continue Reading

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Citations

Oct 4, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Edson José FragiorgeMário Antônio Spanó
Nov 1, 2009·International Journal of Consumer Studies·Sam-Ang SeubsmanAdrian Sleigh
Nov 26, 2009·BMC Complementary and Alternative Medicine·S BrijeshTannaz Birdi
Nov 5, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Zahira Fernández-Bedmar, Angeles Alonso-Moraga
Jun 24, 2017·Journal of Natural Medicines·Pornsiri PitchakarnPornngarm Limtrakul
Nov 20, 2018·Journal of Dietary Supplements·Nurudeen S AdigunTaofeek O Ajiboye
Jun 3, 2017·Food Science & Nutrition·Phatcharaporn BudluangArisa Imsumran

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