PMID: 3989682Feb 1, 1985Paper

Effect of diffusion layer pH and solubility on the dissolution rate of pharmaceutical bases and their hydrochloride salts. I: Phenazopyridine

Journal of Pharmaceutical Sciences
A T Serajuddin, C I Jarowski

Abstract

The pH-solubility profile of phenazopyridine as determined by the addition of HCl or NaOH solutions to its aqueous suspension was identical to that of its hydrochloride salt except during phase transition from base to salt. With the addition of HCl to a suspension of the base, the pH dropped to a certain point and then remained constant until a supersaturated solution was formed. Only after a high supersaturation did precipitation of the hydrochloride salt occur. The solubility of the salt decreased at low pH due to a common ion effect. Unlike solubility profiles, the pH-intrinsic dissolution rate profiles of the base and its salt differed greatly. At low pH, the dissolution rate of the hydrochloride salt decreased with an increase in HCl concentration, whereas the dissolution rate of the base increased. The self-buffering action of the base and the increase in solubility, leading to a supersaturation of the diffusion layer was responsible for the increase in its dissolution rate with a lowering of the pH of the medium. Good conformity with the Noyes-Whitney equation was demonstrated when the solubility values under pH conditions such that the diffusion layer thickness approaches zero (Cs,h = 0) were used rather than solubiliti...Continue Reading

References

Sep 1, 1978·Journal of Pharmaceutical Sciences·Z T Chowhan

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Citations

Jun 23, 2009·Pharmaceutical Research·Konstantin TsinmanDmytro Voloboy
Sep 5, 2001·International Journal of Pharmaceutics·K M O'Connor, O I Corrigan
Apr 19, 2013·AAPS PharmSciTech·Lokesh KumarArvind Bansal
Mar 3, 2012·Drug Development and Industrial Pharmacy·Benjamin M CollmanAnthony C Blackburn
Jan 4, 2012·Journal of Pharmaceutical Sciences·Kristyn Greco, Robin Bogner
Sep 2, 2005·Journal of Pharmaceutical Sciences·Shoufeng LiAbu T M Serajuddin
Feb 20, 2014·Journal of Pharmaceutical Sciences·Divyakant DesaiPeter Timmins
Sep 20, 2007·Journal of Pharmaceutical Sciences·Jeremy GuoJames N Herron
Jun 30, 2005·Journal of Pharmaceutical Sciences·Kaisa R HänninenJouni T Hirvonen
Feb 26, 2016·Journal of Pharmaceutical Sciences·Boris Shekunov, Eda Ross Montgomery
Jan 18, 2011·International Journal of Pharmaceutics·Ying LuKinam Park
Jul 10, 2007·Advanced Drug Delivery Reviews·Abu T M Serajuddin
Jul 22, 2004·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Christel A S BergströmPer Artursson
Apr 10, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Nozomi HisadaShinji Yamashita
Sep 11, 2007·Drug Metabolism and Pharmacokinetics·Kiyohiko SuganoTakashi Mano
May 4, 2016·Advanced Drug Delivery Reviews·Gislaine KuminekNaír Rodríguez-Hornedo
Jun 25, 2016·Molecular Pharmaceutics·Hiroshi KoyamaKiyohiko Sugano
Nov 4, 2016·Drug Development and Industrial Pharmacy·Frank A Chrzanowski, Kaleem Ahmad
Apr 25, 2007·Journal of Pharmaceutical Sciences·Sherif I Farag Badawy, Munir A Hussain
Nov 26, 2009·Chemistry & Biodiversity·Alex AvdeefDmytro Voloboy
Feb 7, 2013·Pharmacological Reviews·Hywel D WilliamsChristopher J H Porter
Apr 1, 1987·The Journal of Pharmacy and Pharmacology·R DahlanV B Sunderland
Sep 10, 2020·Pharmaceutics·Naoya MatsumuraKiyohiko Sugano
Mar 10, 2017·Drug Development and Industrial Pharmacy·Haichen NieQi Tony Zhou

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