PMID: 8976249Jan 1, 1997Paper

Effect of digital rectal examination and needle biopsy on serum total and percentage of free prostate specific antigen levels

The Journal of Urology
D K OrnsteinW J Catalona

Abstract

We determined the effect of digital rectal examination and prostatic biopsy on serum total and free prostate specific antigen (PSA) concentrations in men undergoing screening for prostate cancer. In 93 men recruited from our PSA screening program we measured the serum concentrations of total and free PSA on 3 occasions during a 30-day interval before performing digital rectal examination. Total and free PSA measurements were repeated 1 and 24 hours after the rectal examination. Serum total and free PSA also was measured immediately before, and 1 hour, 24 hours and 1 week after prostatic biopsy in 30 men. Biological variation for total and free PSA was 14.7 and 14.0%, respectively. At 1 hour after rectal examination total and free PSA increased by more than the biological variation in 31 and 48% of the men, respectively. Increases were significantly greater in men whose initial PSA concentrations were less than 4.0 ng./ml. There was a dramatic increase in total and percentage of free PSA in all men 1 hour after prostatic biopsy. Increases in percentage of free PSA were greater in men whose biopsies revealed cancer. Total PSA remained elevated for at least 1 week in most men, while percentage of free PSA returned to within or les...Continue Reading

Citations

Jun 27, 2002·Current Urology Reports·M HanA W Partin
Mar 31, 2012·Science Translational Medicine·John R PrensnerArul M Chinnaiyan
Nov 6, 1998·Clinical Chemistry and Laboratory Medicine : CCLM·R Daher, M Beaini
Apr 15, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Markus HerrmannWolfgang Herrmann
Jan 18, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Yilmaz AksoyFatih Akçay
Apr 16, 1998·Pathology·K A SikarisM D Guerin
May 6, 2015·Prostate Cancer and Prostatic Diseases·D JiandaniD Santa Mina
Aug 3, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Ronan LongKevin Moran
Jun 29, 2010·The Laryngoscope·Sema Zer TorosIzzet Titiz
Oct 6, 1998·Critical Reviews in Clinical Laboratory Sciences·H G RittenhouseA W Partin
Feb 21, 2018·The Prostate·Michael A MacciniElward David Crawford
Mar 10, 2000·International Journal of Urology : Official Journal of the Japanese Urological Association·Y FuruyaH Ito
Oct 13, 2006·The Prostate·Vikas KundraNora M Navone
Oct 17, 2007·Journal of Clinical Ultrasound : JCU·Erdinc SerinErdal Karavas
Mar 16, 2001·Expert Opinion on Pharmacotherapy·D K Ornstein, R S Pruthi
Oct 14, 2006·Current Opinion in Urology·U H StenmanP Wu
Aug 5, 2000·Current Opinion in Urology·M R Feneley, A W Partin
Mar 4, 2020·Animals : an Open Access Journal From MDPI·Salvatore AlongeGiulio G Aiudi

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