PMID: 9446006Jan 31, 1998Paper

Effect of diltiazem on concentration of cyclosporin metabolites in Sandimmune and Neoral treated kidney transplant patients

Medizinische Klinik
H SperschneiderU Christians

Abstract

Diltiazem reduces the cyclosporine dose required for blood levels in the therapeutic target range by 30 to 40%. The effect of diltiazem on the pharmacokinetic disposition of cyclosporine after oral Neoral application is unknown and it is unclear whether or not the diltiazem-cyclosporine interaction is affected by the galenic cyclosporine formulation. Fifty-one stable renal allograft patients (19 females, 32 males) were enrolled in this prospective, randomized and double-blind study. The patients were assigned to 3 treatment groups: with diltiazem (I, n = 17), with nifedipine (II, n = 17) and without calcium channel blockers (III, n = 17). Nine patients in each group received Sandimmun and 8 patients Neoral. Blood concentrations of cyclosporine and its metabolites AM1 and AM9 were measured using HPLC for 12 weeks. The 3 treatment groups were not different in respect to age, gender distribution and serum creatinine concentration. Cyclosporine doses were adjusted on basis of the blood levels. The cyclosporine doses required to achieve target blood levels were significantly lower in group I compared with group II (-43%) and group III (-33%; p < 0.0001). Although the cyclosporine blood concentrations in all groups were in the therap...Continue Reading

References

Dec 14, 1991·Lancet·J C KolarsP B Watkins
Jan 1, 1990·European Journal of Clinical Pharmacology·J BrockmöllerI Roots
Jan 1, 1987·Transplantation·B M FreedN Lempert
Oct 1, 1994·Pharmacogenetics·J C KolarsP B Watkins
Mar 1, 1996·Clinical Pharmacology and Therapeutics·T ChangM F Hebert

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Citations

May 31, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anna PisanoCarmine Zoccali
Jul 10, 2009·The Cochrane Database of Systematic Reviews·Nicholas B CrossJonathan C Craig
Feb 28, 2021·Kidney International·UNKNOWN Kidney Disease: Improving Global Outcomes (KDIGO) Blood Pressure Work Group

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