Effect of Dipsaci radix on hind limb muscle atrophy of sciatic nerve transected rats

The American Journal of Chinese Medicine
Hyuk-Sang JungYoungjoo Sohn

Abstract

It was reported that Dipsaci radix (DR) has a reinforcement effect on the bone-muscle dysfunction in the oriental medical classics and the experimental animal studies. The muscle atrophy was induced by unilateral transection of the sciatic nerve of the rats. Water-extract of DR was used as treatment once a day for 12 days. The muscle weights of the hind limb, atrophic changes, glycogen contents, compositions and cross-section areas of muscle fiber types in soleus and medial gastrocnemius were investigated. Muscle fiber type was classified to type-I and type-II with MHCf immunohistochemistry. Furthermore, Bax and Bcl-2 expressions were observed with immunohistochemiatry. DR treatment significantly increased muscle weights of soleus, medial gastrocnemius, lateral gastrocnemius, and posterior tibialis of the damaged hind limb. DR treatment reduced apoptotic muscle nuclei and hyaline-degenerated muscle fibers in soleus and medial gastrocnemius of the damaged hind limb. DR treatment also significantly increased glycogen contents in medial gastrocnemius of the damaged hind limb. DR treatment significantly attenuated the slow-to-fast shift in soleus of the damaged hind limb but not in medial gastrocnemius. DR treatment significantly i...Continue Reading

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Citations

Oct 16, 2010·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Xuhui LiuBrian T Feeley
Aug 19, 2015·International Journal of Biological Macromolecules·Li-Hong TanWei-Guo Cao
Dec 29, 2012·International Journal of Biological Macromolecules·Guangting CongLirong Hao

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