Effect of Direct-Acting Antiviral Therapy on Thrombocytopenic Patients with Hepatitis C Virus-Related Chronic Liver Disease.

Gastroenterology Research and Practice
Mahmoud Saif-Al-IslamSafaa Khalaf

Abstract

Thrombocytopenia is a common complication in patients with chronic hepatitis C virus (HCV) that increases the risk of bleeding. We aimed to analyze the hematologic effects of the new direct-acting antiviral (DAA) therapy, particularly on the platelet count in chronic HCV-infected patients with thrombocytopenia. Patients and Methods. One hundred thrombocytopenic patients chronically infected with HCV were included in a prospective study. All patients were eligible for receiving anti-HCV treatment with sofosbuvir-based regimens for 12 weeks, according to the protocol of the National Program for treatment of HCV in Egypt sponsored by the Ministry of Health. At the end of treatment (EOT), there was a highly significant increase in platelet count (p < 0.001), a significant increase in white blood cells (WBCs) count (p ≤ 0.032), and a highly significant decrease in hemoglobin level (p < 0.001) as compared to pretreatment levels. Patients with mild to moderate hepatic fibrosis had significantly higher median and interquartile range (IQR) platelet count at baseline and EOT than those with advanced fibrosis and cirrhosis (p ≤ 0.023 and p < 0.001, respectively). There was more elevation in platelet count at EOT in patients with mild to m...Continue Reading

References

Oct 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T PoynardJ Albrecht
Jul 7, 2001·The New England Journal of Medicine·G M Lauer, B D Walker
May 20, 2003·Journal of Gastroenterology and Hepatology·Akira SanjoNaoki Suzuki
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chun-Tao WaiAnna S-F Lok
Jul 18, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Chun-Tao WaiSeng Gee Lim
Apr 25, 2008·Journal of Hepatology·Nezam AfdhalRafael Esteban
Mar 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marc G GhanyUNKNOWN American Association for the Study of Liver Diseases
Aug 28, 2010·Journal of Viral Hepatitis·K S LouieU M Forssen
Feb 14, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Makoto OsadaYukio Ozaki
Dec 22, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Patricia F LalorDavid H Adams
Jan 4, 2013·The New England Journal of Medicine·Edward J GaneM Michelle Berrey
May 17, 2013·The New England Journal of Medicine·T Jake Liang, Marc G Ghany
Jan 1, 2014·Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation·Yasser M Fouad
Apr 15, 2014·The New England Journal of Medicine·Fred PoordadBarry Bernstein
Apr 15, 2014·The New England Journal of Medicine·Nezam AfdhalUNKNOWN ION-2 Investigators
Apr 26, 2015·Journal of Hepatology·UNKNOWN European Association for Study of Liver, UNKNOWN Asociacion Latinoamericana para el Estudio del Higado
Dec 10, 2015·Journal of Gastroenterology and Hepatology·Adriaan J van der MeerHarry LA Janssen
Oct 22, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Abhishek ChauhanPatricia F Lalor
Oct 7, 2016·Annals of Gastroenterology : Quarterly Publication of the Hellenic Society of Gastroenterology·Zannis AlmpanisDina Tiniakos
Nov 20, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Markus Peck-Radosavljevic
Apr 14, 2018·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu, UNKNOWN European Association for the Study of the Liver
Jul 12, 2018·Hepatology International·Tatsuo KandaMitsuhiko Moriyama
Oct 23, 2018·World Journal of Gastroenterology : WJG·Dalia OmranMohamed El Kassas
Nov 30, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masanori AtsukawaKatsuhiko Iwakiri

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.