Effect of discontinuation of fluoride intake from water and toothpaste on urinary excretion in young children

International Journal of Environmental Research and Public Health
Carolina Castro MartinsJaime A Cury


As there is no homeostatic mechanism for maintaining circulating fluoride (F) in the human body, the concentration may decrease and increase again when intake is interrupted and re-started. The present study prospectively evaluated this process in children exposed to F intake from water and toothpaste, using F in urine as a biomarker. Eleven children from Ibiá, Brazil (with sub-optimally fluoridated water supply) aged two to four years who regularly used fluoridated toothpaste (1,100 ppm F) took part in the study. Twenty-four-hour urine was collected at baseline (Day 0, F exposure from water and toothpaste) as well as after the interruption of fluoride intake from water and dentifrice (Days 1 to 28) (F interruption) and after fluoride intake from these sources had been re-established (Days 29 to 34) (F re-exposure). Urinary volume was measured, fluoride concentration was determined and the amount of fluoride excreted was calculated and expressed in mg F/day. Urinary fluoride excretion (UFE) during the periods of fluoride exposure, interruption and re-exposure was analyzed using the Wilcoxon test. Mean UFE was 0.25 mg F/day (SD: 0.15) at baseline, dropped to a mean of 0.14 mg F/day during F interruption (SD: 0.07; range: 0.11 to...Continue Reading

Associated Clinical Trials


Feb 1, 1975·Journal of Applied Physiology·H SpencerE Wiatrowski
Feb 1, 1990·Journal of Dental Research·G M Whitford
Jan 1, 1984·Caries Research·J EkstrandC J Spak
Jul 1, 1994·Advances in Dental Research·J EkstrandS J Fomon
Jan 1, 1995·Caries Research·R A Warpeha, T M Marthaler
Jun 1, 1994·Advances in Dental Research·R Ophaug
Oct 26, 1999·Caries Research·G M WhitfordF R von der Fehr
Feb 22, 2000·Journal of Public Health Dentistry·G M Whitford
Feb 22, 2000·Journal of Public Health Dentistry·S J Fomon, J Ekstrand
Oct 3, 2000·Community Dentistry and Oral Epidemiology·A VillaL Cabezas
Apr 20, 2001·International Journal of Paediatric Dentistry·C E Ketley, M A Lennon
Jan 19, 2002·Caries Research·M HaftenbergerG Hetzer
May 20, 2003·Community Dentistry and Oral Epidemiology·Saul M PaivaJaime A Cury
Aug 20, 2003·Caries Research·Y B O Lima, J A Cury
Feb 14, 2004·Revista de saúde pública·Mitsue Fujimaki HayacibaraJaime Aparecido Cury
Mar 16, 2004·Community Dentistry and Oral Epidemiology·Clare E KetleyDenis M O'Mullane
Nov 24, 2005·Journal of Dental Research·J A CuryP L Rosalen
Jun 26, 2007·Revista de saúde pública·Renato C V CasarinJaime A Cury
Jul 27, 2007·Journal of Dental Research·L G Do, A J Spencer
Jul 20, 2010·Brazilian Dental Journal·Ynara Bosco Oliveira Lima-ArsatiJaime Aparecido Cury

❮ Previous
Next ❯


Nov 6, 2013·International Journal of Environmental Research and Public Health·Maria José L OliveiraJaime A Cury
Dec 14, 2011·International Journal of Environmental Research and Public Health·Carolina Castro MartinsSaul Martins Paiva
Nov 20, 2015·Scientific Reports·Fatemeh V ZohooriAnne Maguire
Apr 12, 2015·Regulatory Toxicology and Pharmacology : RTP·L L AylwardA Nong
Apr 15, 2014·Environment International·Amy L HeffernanJ F Mueller
Aug 2, 2019·Journal of Conservative Dentistry : JCD·Fatih Tulumbacı, Aylin Akbay Oba

❮ Previous
Next ❯

Methods Mentioned

urine sampling

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.