Effect of discontinuation of fluoride intake from water and toothpaste on urinary excretion in young children

International Journal of Environmental Research and Public Health
Carolina Castro MartinsJaime A Cury

Abstract

As there is no homeostatic mechanism for maintaining circulating fluoride (F) in the human body, the concentration may decrease and increase again when intake is interrupted and re-started. The present study prospectively evaluated this process in children exposed to F intake from water and toothpaste, using F in urine as a biomarker. Eleven children from Ibiá, Brazil (with sub-optimally fluoridated water supply) aged two to four years who regularly used fluoridated toothpaste (1,100 ppm F) took part in the study. Twenty-four-hour urine was collected at baseline (Day 0, F exposure from water and toothpaste) as well as after the interruption of fluoride intake from water and dentifrice (Days 1 to 28) (F interruption) and after fluoride intake from these sources had been re-established (Days 29 to 34) (F re-exposure). Urinary volume was measured, fluoride concentration was determined and the amount of fluoride excreted was calculated and expressed in mg F/day. Urinary fluoride excretion (UFE) during the periods of fluoride exposure, interruption and re-exposure was analyzed using the Wilcoxon test. Mean UFE was 0.25 mg F/day (SD: 0.15) at baseline, dropped to a mean of 0.14 mg F/day during F interruption (SD: 0.07; range: 0.11 to...Continue Reading

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Citations

Nov 6, 2013·International Journal of Environmental Research and Public Health·Maria José L OliveiraJaime A Cury
Dec 14, 2011·International Journal of Environmental Research and Public Health·Carolina Castro MartinsSaul Martins Paiva
Nov 20, 2015·Scientific Reports·Fatemeh V ZohooriAnne Maguire
Apr 12, 2015·Regulatory Toxicology and Pharmacology : RTP·L L AylwardA Nong
Apr 15, 2014·Environment International·Amy L HeffernanJ F Mueller
Aug 2, 2019·Journal of Conservative Dentistry : JCD·Fatih Tulumbacı, Aylin Akbay Oba

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Methods Mentioned

BETA
urine sampling

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