Effect of disease duration on the association between serum albumin and mucosal healing in patients with ulcerative colitis.

BMJ Open Gastroenterology
Sen YagiYoichi Hiasa

Abstract

Serum albumin is used as a marker of acute inflammation. Several studies have addressed the association between serum albumin and clinical outcome in patients with ulcerative colitis (UC). While mucosal healing (MH) has been indicated as the therapeutic goal for UC, the association between serum albumin and MH remains unclear. We evaluated this issue in patients with UC overall and explored whether duration of UC affected this association. This cross-sectional study recruited consecutive patients with UC. Study subjects consisted of 273 Japanese patients with UC. Serum albumin was divided into tertiles based on its distribution in all study subjects. One endoscopy specialist was responsible for measuring partial MH and MH, which were defined as a Mayo endoscopic subscore of 0-1 and 0, respectively. The association between serum albumin and clinical outcomes was assessed by multivariate logistic regression. Rates of clinical remission, partial MH and MH were 57.9%, 63% and 26%, respectively. Only high serum albumin (>4.4 mg/dL) was significantly positively associated with MH (OR 2.29 (95% CI: 1.03 to 5.29), p for trend=0.043). In patients with short UC duration (<7 years) only, high serum albumin was significantly positively ass...Continue Reading

References

Dec 24, 1987·The New England Journal of Medicine·K W SchroederD M Ilstrup
Jun 1, 1996·Gut·S P TravisD P Jewell
Oct 16, 2004·Journal of Gastroenterology and Hepatology·Sanjay KumarGourdas Choudhuri
Jan 22, 2005·Seminars in Dialysis·Burl R Don, George Kaysen
Apr 28, 2010·International Journal of Clinical Pharmacology and Therapeutics·A A FasanmadeH M Davis
May 31, 2011·Scandinavian Journal of Gastroenterology·Petr RicanekUNKNOWN IBSEN II Study Group
Jun 20, 2014·Canadian Journal of Gastroenterology & Hepatology·Mayur Brahmania, Charles N Bernstein
May 13, 2015·Canadian Journal of Gastroenterology & Hepatology·Travis MurdochRemo Panaccione
Aug 1, 2015·Journal of Nutritional Science and Vitaminology·Yukiko OeToshinao Goda
Jul 25, 2017·Journal of Clinical Gastroenterology·David J GibsonGlen A Doherty
Nov 9, 2017·International Journal of Molecular Medicine·Shuhei FukunagaTakuji Torimura
Feb 6, 2018·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Vanesa JusuéJavier P Gisbert
Jul 4, 2018·Scandinavian Journal of Gastroenterology·Katrine CarlsenPia Munkholm
Aug 1, 2018·Best Practice & Research. Clinical Gastroenterology·Gaetano GalloAntonino Spinelli
Nov 30, 2018·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Mayu UchiharaMasayuki Kitano
Dec 26, 2018·Journal of Medical Biochemistry·Muhammet Yener AkpinarErtugrul Kayacetin
Aug 14, 2019·Journal of Crohn's & Colitis·Jean-Frédéric ColombelRemo Panaccione
Jun 6, 2020·Diagnostics·Małgorzata Krzystek-KorpackaKatarzyna Neubauer
Oct 31, 2020·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·David C EvansUNKNOWN ASPEN Malnutrition Committee

❮ Previous
Next ❯

Software Mentioned

SAS
JMP

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved