Abstract
The relationship between passive tension applied to aortic rings and the resulting increase in tissue length was nearly linear over the range of 1 to 15 g. However, even with increasing tissue length, within the range of 1 to 10 g passive tension, the total active force generated upon stimulation was not significantly changed. These observations emphasize the great flexibility of the mechanism(s) underlying the contractile response of vascular smooth muscle with regard to changes in tissue preload and length. Neither the blockade of microtubule polymerization by colchicine nor the blockade of actin polymerization by cytochalasin B significantly changed the slope of the tissue length-preload curve, indicating no effect on the tissues' capacity to stretch at a given preload. With stimulation of the tissue at different levels of stretch, colchicine caused an increase in the initial fast component of active tension development, but partially blocked the secondary slow rise in tension. Cytochalasin B dramatically reduced the total contractile response at each preload studied, and this effect was confined almost exclusively to the secondary slow increase in tension. When tissues were cooled to cause complete dissolution of the microt...Continue Reading
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