Effect of disulfiram on the ultrastructure of the peptidergic and aminergic cells in the pars intercerebralis of Galleria mellonella (Lepidoptera)

Cell and Tissue Research
S Wartoń

Abstract

Injection of disulfiram, a specific inhibitor of noradrenaline synthesis, evokes changes in two different types of neurons in the brain of Galleria mellonella: neurones containing dense-core vesicles (60-80 nm) and peptidergic cells containing 180-200 nm neurosecretory granules. The lowering of the electron density of the dense-core vesicles of 60-80 nm seems to be directly connected with disulfiram administration, while the decrease of the amount of neurosecretory material in the neurosecretory cells of type I seems to be a secondary effect of the drug injection. The participation of noradrenaline in the regulation of the secretory activity of type I peptidergic neurosecretory cells of the pars intercerebralis is postulated.

References

Jun 15, 1984·European Journal of Pharmacology·B Ahrén, I Lundquist
Dec 4, 1990·European Journal of Pharmacology·S Karlsson, B Ahrén
Jan 1, 1986·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·K S RózsaL Hiripi
Jul 13, 2002·The Journal of Comparative Neurology·Hideki MatsudaTomas Hökfelt

Citations

Jan 1, 1976·Progress in Neurobiology·N Klemm
May 1, 1978·Journal of Neurochemistry·P D Evans
Feb 1, 1978·General and Comparative Endocrinology·N Klemm, B Falck
Jun 1, 1966·Journal of Molecular Biology·E Appella, G M Tomkins

Related Concepts

Brain Diseases
Set of Aminergic Cells
Electron Density
Neurons
Brain
Galleria mellonella
Vesicle
Antheraea
Norepinephrine
Norepinephrine Measurement

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