Oct 1, 1978

Effect of diuretic, beta-adrenoceptor blocking agent and their combination on elevated blood pressure and serum potassium: a cross-over study

British Journal of Clinical Pharmacology
P J NeuvonenA J Jounela

Abstract

1. The antihypertensive effect of a new beta-adrenoceptor blocking agent, trimepranol (10--14 mg/twice daily), chlorthalidone (50 mg every second day) and their combination was studied in eighteen patients with mild to moderate essential hypertension. In a controlled randomized cross-over study the drugs were given for 6 week periods. 2. A significant and equal decrease in blood pressure was achieved both with trimepranol and chlorthalidone, whereas their combination was significantly more effective. 3. Trimepranol significantly antagonized the chlorthalidone-induced hypokalemia. 4. The results favor the use of diuretic or diuretic-beta-adrenoceptor blocker combination over beta-adrenoceptor blocker monotherapy in the treatment of mild to moderate hypertension.

Mentioned in this Paper

Diastolic Blood Pressure
Potassium
Serum Potassium Measurement
Polychemotherapy
Essential Hypertension
Cross-Over Studies
Disorat
Propanolamines
Thalitone
Chlorthalidone

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