Effect of DMSO and exchange volume on outflow resistance washout and response to pilocarpine during anterior chamber perfusion in monkeys

Current Eye Research
J A KilandP L Kaufman

Abstract

To determine the dependence of outflow resistance washout on anterior chamber (AC) fluid exchange volume (EV); the minimum EV required for complete AC mixing, and the effect of 0.01-5% DMSO in the exchange solution on outflow resistance. Total outflow facility was determined in 63 pentobarbital-anesthetized cynomolgus monkeys, before and after AC exchange, for 10 min, with 1, 2, and 4 ml of Bárány's perfusand, containing 0.01-5% DMSO or containing 1 microgram/ml or 5 micrograms/ml pilocarpine HCL (pilo), each volume. Post-exchange facility increased by 21% (p < 0.05) vs. baseline for both the 1 and 2 ml Bárány's volumes and by 50% (p < 0.001) for the 4-ml volume. Washout-corrected post-exchange facility was unchanged from baseline, following 1 or 2 ml exchange with 1 microgram/ml pilo; 5 micrograms/ml pilo increased facility by 130 +/- 41% and 174 +/- 40% respectively, relative to baseline. Exchange with 4 ml of 1 microgram/ml pilo increased facility 72% more than the 2 ml (p < 0.029) and 100% more than the 1 ml (p < 0.014) volumes. When corrected for their respective baselines, 2 ml of 5 micrograms/ml pilo increased facility 12.7 +/- 4.4% more than the 1 ml volume (p < 0.05). Post exchange facility was not significantly increa...Continue Reading

References

Feb 1, 1973·American Journal of Ophthalmology·C F AsseffB Becker
Jan 1, 1981·Journal of Toxicology and Environmental Health·J C de la TorreR Wollmann
Jul 1, 1959·A.M.A. Archives of Ophthalmology·R G JANES, J F STILES

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Citations

May 23, 2006·Current Eye Research·J A KilandP L Kaufman
Feb 13, 2002·Current Eye Research·B T GabeltP L Kaufman
Dec 15, 2010·Experimental Eye Research·B'Ann T GabeltCarol A Rasmussen
Feb 18, 2010·Experimental Eye Research·Mark Wendt, Adrian Glasser
Nov 30, 2000·Experimental Eye Research·B TianP L Kaufman
Jan 31, 2006·Experimental Eye Research·Yujie HuPaul L Kaufman
Jun 22, 1999·Experimental Eye Research·B TianP L Kaufman

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