Effect of Docosahexaenoic Acid on Apoptosis and Proliferation in the Placenta: Preliminary Report

BioMed Research International
Ewa WietrakJan Oleszczuk

Abstract

Observational studies confirm a higher incidence of preeclampsia in patients with low erythrocyte concentrations of omega-3 fatty acids. Observations point to an association of disorders of pregnancy, such as intrauterine growth restriction (IUGR) and preeclampsia, with excessive apoptosis. One potential mechanism of action of docosahexaenoic acid (DHA) promoting a reduction in the risk of pathological pregnancy may be by influencing these processes in the placenta. We investigated 28 pregnant women supplemented with a fish oil product containing 300 mg DHA starting from pregnancy week 20 until delivery (DHA group). The control group consisted of 50 women who did not receive such supplementation (control group). We determined the expression of Ki-67 and p21 as markers of proliferation and caspase 3 activity as a marker of apoptosis and DHA levels in umbilical cord blood. Caspase 3 activity was significantly lower in the DHA group in comparison to the control group. Umbilical cord blood DHA concentration was higher in the DHA group. The expression of the proteins p21 and Ki-67 did not differ significantly between the groups. We observed an association between DHA supplementation and inhibition of placental apoptosis. We did not ...Continue Reading

Associated Clinical Trials

Jul 12, 2017·Fátima Lúcia de Carvalho Sardinha

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Citations

Jan 26, 2021·Clinical Therapeutics·Alison J EastmanDavid M Aronoff
Dec 29, 2020·Clinical Therapeutics·Aisha RasoolPerrie O'Tierney-Ginn

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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