PMID: 9422343Jan 9, 1998Paper

Effect of docosahexaenoic acid on the synthesis of phosphatidylserine in rat brain in microsomes and C6 glioma cells

Journal of Neurochemistry
M C GarciaH Y Kim

Abstract

Docosahexaenoic acid (22:6n-3) is the major polyunsaturated fatty acid (PUFA) in the CNS and accumulates particularly in phosphatidylserine (PS). We have investigated the effect of the 22:6n-3 compositional status on the synthesis of PS. The fatty acid composition of brain microsomes from offspring of rats artificially reared on an n-3-deficient diet showed a dramatic reduction of 22:6n-3 content (1.7 +/- 0.1%) when compared with control animals (15.0 +/- 0.2%). The decrease was accompanied by an increase in docosapentaenoic acid (22:5n-6) content, which replaced the 22:6n-3 phospholipids with 22:5n-6 molecular species, as demonstrated using HPLC/electrospray mass spectrometry. The n-3 deficiency did not affect the total amount of polyunsaturated phospholipids in brain microsomes; however, it was associated with a decrease in the total polyunsaturated PS content and with increased levels of 1-stearoyl-2-docosapentanoyl (18:0/22:5n-6) species, particularly in phosphatidylcholine. Incorporation of [3H]serine into PS in rat brain microsomes from n-3-deficient animals was slightly but significantly less than that of the control animals. Similarly, C6 glioma cells cultured for 24 h in 22:6n-3-supplemented media (10-40 microM) showed...Continue Reading

Citations

Sep 21, 2007·Nature Reviews. Neuroscience·Daniele PiomelliRao Rapaka
Jun 11, 2004·Journal of Neurochemistry·Zhiming Wen, Hee-Yong Kim
Oct 28, 2008·Journal of Neuroscience Research·Frankis G AlmaguelMarino De Leon
Mar 28, 2007·Journal of Neuroscience Research·Zhiming Wen, Hee-Yong Kim
Jul 5, 2011·Expert Review of Neurotherapeutics·Vicent Balanzá-MartínezFlávio Kapczinski
Nov 13, 2014·Nature Reviews. Neuroscience·Richard P Bazinet, Sophie Layé
Dec 21, 2019·Journal of Experimental & Clinical Cancer Research : CR·Yi DingXianqun Fan
Mar 6, 2003·Lipids·Andrew J SinclairDuo Li
Jul 10, 2003·Lipids·Hee-Yong KimAudrey Lau
Sep 29, 2007·Journal of Molecular Neuroscience : MN·Mingquan GuoHee-Yong Kim
Feb 17, 2017·Journal of Lipid Research·Blake R HopiavuoriRobert E Anderson
Feb 24, 2016·Nutrients·Michael J WeiserM Hasan Mohajeri
Feb 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·László G PuskásTibor Farkas
Oct 11, 2005·Annual Review of Cell and Developmental Biology·Joseph R Marszalek, Harvey F Lodish
Jan 7, 2006·Journal of Neuroscience Research·Mohammed AkbarHee-Yong Kim
May 10, 2007·The Journal of Biological Chemistry·Hee-Yong Kim
Dec 15, 2005·Journal of Lipid Research·Anindita JoardarSumantra Das
Mar 26, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Lloyd A Horrocks, Akhlaq A Farooqui
May 5, 2009·The Journal of Nutritional Biochemistry·Júlia D MoreiraLúcia Vinadé

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.