Effect of donor age and ischemic time on intermediate survival and morbidity after lung transplantation

Chest
D M MeyerJ D Hosenpud

Abstract

Pressure to expand the donor pool has required the use of lungs from older donors or from more-distant procurement areas. The long-term consequences of this policy have not yet been fully addressed. The effect of donor age and donor ischemic time on intermediate survival and important secondary end points after lung transplantation was therefore examined. A cohort of 1,800 lung transplant recipients with complete 2-year follow-up, operated on in the United States between April 1, 1993, and March 31, 1996, was studied to assess survival. For analysis of secondary end points, the cohort was limited to 1,450 patients. Donor age when analyzed independently did not significantly affect intermediate survival (p = 0.4). Secondary end points were also not affected by age, with the exception of the incidence of hospitalization for rejection in the univariate analysis (p = 0.02) and in the multivariate analysis (p = 0.04). Moreover, there was not a significant impact of donor age or ischemic time independently on survival in the multivariate analysis. Similarly, when the interaction between ischemic time and donor age was examined in all of the multivariate models, none of the secondary end points were found to be significantly influence...Continue Reading

References

Jun 1, 1995·The Journal of Thoracic and Cardiovascular Surgery·S SundaresanG A Patterson
Dec 1, 1993·The Annals of Thoracic Surgery·S SundaresanJ D Cooper
Jan 1, 1994·The Annals of Thoracic Surgery·G Y OttA Cobanoglu
Jan 1, 1994·The Annals of Thoracic Surgery·S J ShumwayR M Bolman
Jul 1, 1996·The Annals of Thoracic Surgery·M C MauneyC G Tribble
Sep 1, 1996·The Annals of Thoracic Surgery·K E SommersR J Keenan
Jun 11, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·R J NovickJ D Hosenpud

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Citations

Oct 24, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Iskander Al-GithmiAnthony Yim
Oct 31, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jonathan B OrensUNKNOWN Pulmonary Council, International Society for Heart and Lung Transplantation
Feb 9, 2005·Transplantation·Steven M KawutSelim M Arcasoy
Mar 5, 2003·American Journal of Respiratory and Critical Care Medicine·Bruce A JohnsonSteven R Duncan
Jan 12, 2013·American Journal of Respiratory and Critical Care Medicine·Joshua M DiamondUNKNOWN Lung Transplant Outcomes Group
Mar 28, 2008·Respiratory Research·Niels P van der KaaijAd J J C Bogers
Aug 12, 2014·The Annals of Thoracic Surgery·Sharven TaghaviYoshiya Toyoda
May 27, 2009·Current Opinion in Organ Transplantation·Phil Botha
Nov 5, 2011·The Annals of Thoracic Surgery·Sara A HennessyChristine L Lau
Apr 23, 2011·Clinics in Chest Medicine·James C Lee, Jason D Christie
Feb 24, 2011·Medicina intensiva·E MiñambresM A Ballesteros
Oct 23, 2010·Revue des maladies respiratoires·S QuétantC Pison
Jun 11, 2010·Transplantation Proceedings·M C DezzaM Colledan
Mar 31, 2009·Transplantation Proceedings·C MeersUNKNOWN UZ Leuven Council for Transplantation
Jan 30, 2007·The Journal of Thoracic and Cardiovascular Surgery·Marc De PerrotShaf Keshavjee
Feb 26, 2009·Clinical Transplantation·Catherine L KuntzJason D Christie
Jul 19, 2003·Clinical Transplantation·Antonio López-Navidad, Francisco Caballero
Feb 14, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H KanedaS Keshavjee
Sep 17, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M R BaldwinD J Lederer
Aug 14, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J-C ChangS S Lin
Nov 22, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Christopher M BurtonUNKNOWN Copenhagen National Lung Transplant Group
Apr 12, 2005·The Journal of Thoracic and Cardiovascular Surgery·Stefan FischerMartin Strüber
Mar 31, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Heyman LuckrazJohn Wallwork
May 27, 2015·Clinical Transplantation·Alainna J JamalShahid Husain
Feb 22, 2011·Transplantation Proceedings·P M Pêgo-FernandesF B Jatene
Sep 28, 2014·Interactive Cardiovascular and Thoracic Surgery·Iker LópezMercedes Canela
Oct 14, 2003·Chest·Jason D ChristieStephen E Kimmel
Feb 3, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Y FuruyaY Toyoda
Oct 21, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L HeylenJ Pirenne
Mar 22, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J-Q TaoS Chatterjee
Oct 5, 2017·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Matthias HeckerKonstantin Mayer
Jan 1, 2012·Current Respiratory Care Reports·James C LeeJason D Christie
Jun 22, 2020·The Journal of Thoracic and Cardiovascular Surgery·Ashley Y ChoiMatthew G Hartwig
Jan 8, 2021·BMC Medical Informatics and Decision Making·Darren E StewartRebecca E Goff
Jun 5, 2021·PloS One·J M Dueñas-JuradoC Hervás-Martínez
Sep 19, 2003·Chest Surgery Clinics of North America·Clemens AignerWalter Klepetko
Sep 27, 2020·The Journal of Thoracic and Cardiovascular Surgery·William D GerullVarun Puri

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