Effect of dopamine on NaCl transport in the medullary thick ascending limb of the rat

European Journal of Pharmacology
J GriderB Jackson

Abstract

The aim of the present study was to determine whether dopamine affects NaCl reabsorption in the medullary thick ascending limb of the loop of Henle. Basolateral dopamine (10(-6) M) significantly inhibited Cl- reabsorption in the in vitro microperfused rat medullary thick ascending limb by 21 +/- 2% (P < 0.01). The response to 10(-6) M dopamine was completely blocked by pretreatment with the dopamine D1 receptor antagonist R(+)-SCH-23390 (5 x 10(-5) M), and was mimicked by the dopamine D1 receptor agonist A-77636 (10(-6) M; delta - 36 +/- 2%; P < 0.05). In contrast, basolateral administration of the dopamine D2 receptor agonist (+)-bromocriptine (10(-6) M) transiently increased Cl- reabsorption by 49 +/- 18% (P < 0.05). Neither the D1 nor the D2 agonist affected Cl- reabsorption when selectively administered to the luminal membrane. These data suggest that the predominant effect of dopamine on the medullary thick ascending limb of the rat is to inhibit the reabsorption of NaCl, a response which is mediated by dopamine D1 receptors.

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Citations

Jul 11, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Xiaoyan WangPedro A Jose
Dec 18, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Chunyu ZengPedro A Jose
Feb 22, 2013·American Journal of Physiology. Renal Physiology·Ming Chang HuOrson W Moe
May 10, 2000·Clinical and Experimental Hypertension : CHE·D P O'Connell, A M Aherne
May 10, 2000·Clinical and Experimental Hypertension : CHE·H BrismarA Aperia
Mar 17, 2011·Advances in Chronic Kidney Disease·Judith BlaineRochelle Cunningham
Nov 19, 2004·Physiological Genomics·Chunyu ZengPedro A Jose
Aug 10, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Fredric L CoeElaine Worcester
Jan 6, 2012·American Journal of Physiology. Renal Physiology·A PaliegeS Bachmann
Jan 31, 2020·Physiological Reviews·Jens Leipziger, Helle Praetorius
Jan 3, 2001·Journal of the American Society of Nephrology : JASN·Takanobu TakezakoKikuo Arakawa

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